RPS6KA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0007165Biological processsignal transduction
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0006978Biological processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_2000381Biological processnegative regulation of mesoderm development
GO_0045992Biological processnegative regulation of embryonic development
GO_0007417Biological processcentral nervous system development
GO_0005730Cellular componentnucleolus
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0004711Molecular functionribosomal protein S6 kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPS6KA6
Protein nameRibosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)
SynonymsRSK4
DescriptionFUNCTION: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. .

AccessionsQ9UK32
ENST00000620340.4 [Q9UK32-2]
ENST00000262752.5 [Q9UK32-1]