LILRA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0140105Biological processinterleukin-10-mediated signaling pathway
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_0002220Biological processinnate immune response activating cell surface receptor signaling pathway
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0002764Biological processimmune response-regulating signaling pathway
GO_0031665Biological processnegative regulation of lipopolysaccharide-mediated signaling pathway
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0071657Biological processpositive regulation of granulocyte colony-stimulating factor production
GO_0050867Biological processpositive regulation of cell activation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0006952Biological processdefense response
GO_0002283Biological processneutrophil activation involved in immune response
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0001791Molecular functionIgM binding
GO_0032396Molecular functioninhibitory MHC class I receptor activity
GO_0003823Molecular functionantigen binding

IV. Literature review

[source]
Gene nameLILRA2
Protein nameLeukocyte immunoglobulin like receptor A2
Leukocyte immunoglobulin like receptor A2 (Leukocyte immunoglobulin-like receptor subfamily A member 2)
Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)
Leukocyte immunoglobulin-like receptor subfamily A member 2
SynonymsLIR7
ILT1
DescriptionFUNCTION: Part of the innate immune responses against microbial infection . Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans . Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling . Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 . Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils . In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 . In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 . Does not bind class I MHC antigens . .

AccessionsENST00000621611.4
ENST00000616629.1
ENST00000628662.1
A0A087WT41
ENST00000472992.1
ENST00000613573.4
ENST00000618818.4
A0A0G2JMC9
ENST00000391737.3
ENST00000612908.4
ENST00000391738.8 [Q8N149-1]
ENST00000251376.7 [Q8N149-2]
A0A0G2JMW8
ENST00000439534.5
Q8N149
ENST00000627076.2
ENST00000617409.4
ENST00000617156.1
A0A0D9SFC7
ENST00000620279.4
ENST00000622640.3
ENST00000612001.4
ENST00000251377.7 [Q8N149-1]
ENST00000615591.3
A8MZH0
A0A0G2JMR2
ENST00000621721.4
E9PDF4
ENST00000628510.2
ENST00000611940.4
ENST00000631297.1