RASIP1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	27% ± 10%	Explore
endothelial cell of lymphatic vessel	14 studies	26% ± 10%	Explore
capillary endothelial cell	13 studies	30% ± 9%	Explore
vein endothelial cell	12 studies	26% ± 7%	Explore
endothelial cell of artery	10 studies	26% ± 8%	Explore
endothelial cell of vascular tree	8 studies	28% ± 10%	Explore
glomerular endothelial cell	3 studies	20% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of RASIP1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2407.91	652 / 653	95%	16.67	573 / 605
uterus	100%	2445.91	170 / 170	95%	36.97	434 / 459
pancreas	100%	1469.20	327 / 328	94%	10.73	168 / 178
adrenal gland	100%	1529.69	258 / 258	93%	15.27	213 / 230
prostate	100%	1410.62	244 / 245	85%	7.75	426 / 502
breast	100%	4483.53	459 / 459	84%	10.36	941 / 1118
esophagus	99%	1529.14	1437 / 1445	85%	10.18	155 / 183
ovary	98%	1265.92	176 / 180	85%	15.66	364 / 430
stomach	100%	1688.44	358 / 359	78%	8.32	224 / 286
bladder	100%	1721.71	21 / 21	78%	13.55	393 / 504
lung	100%	5855.86	578 / 578	76%	8.87	881 / 1155
kidney	100%	1713.36	89 / 89	73%	17.33	660 / 901
intestine	96%	1199.36	929 / 966	74%	6.28	388 / 527
brain	75%	637.44	1976 / 2642	89%	7.75	630 / 705
skin	75%	1050.97	1364 / 1809	73%	21.09	344 / 472
liver	35%	268.01	80 / 226	82%	7.40	334 / 406
adipose	100%	4518.95	1204 / 1204	0%	0	0 / 0
spleen	100%	4113.56	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	11.73	1 / 1
heart	99%	1947.08	855 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	34.59	42 / 45
muscle	86%	674.65	689 / 803	0%	0	0 / 0
blood vessel	73%	877.47	971 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	69%	4.99	20 / 29
eye	0%	0	0 / 0	57%	7.68	46 / 80
peripheral blood	1%	6.40	8 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0010507	Biological process	negative regulation of autophagy
GO_0007165	Biological process	signal transduction
GO_0035024	Biological process	negative regulation of Rho protein signal transduction
GO_0001525	Biological process	angiogenesis
GO_0001570	Biological process	vasculogenesis
GO_0043087	Biological process	regulation of GTPase activity
GO_0033625	Biological process	positive regulation of integrin activation
GO_1905709	Biological process	negative regulation of membrane permeability
GO_0048754	Biological process	branching morphogenesis of an epithelial tube
GO_2000299	Biological process	negative regulation of Rho-dependent protein serine/threonine kinase activity
GO_0005911	Cellular component	cell-cell junction
GO_0005795	Cellular component	Golgi stack
GO_0032991	Cellular component	protein-containing complex
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0051020	Molecular function	GTPase binding
GO_0005515	Molecular function	protein binding

Gene name	RASIP1
Protein name	RASIP1 protein Ras-interacting protein 1 (Rain) Ras interacting protein 1
Synonyms
Description	FUNCTION: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. .
Accessions	Q5U651 Q7L251 M0R148 ENST00000599291.1 ENST00000222145.9 Q8IUR2

RASIP1 report