I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 4 studies | 19% ± 4% | |
| macrophage | 4 studies | 20% ± 4% | |
| alveolar macrophage | 3 studies | 25% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 4 studies | 19% ± 4% | |
| macrophage | 4 studies | 20% ± 4% | |
| alveolar macrophage | 3 studies | 25% ± 7% |
Insufficient scRNA-seq data for expression of TG at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 1619891.23 | 653 / 653 | 92% | 9515.61 | 555 / 605 |
| adrenal gland | 91% | 471.29 | 234 / 258 | 59% | 5.97 | 135 / 230 |
| prostate | 92% | 766.26 | 225 / 245 | 39% | 5.88 | 195 / 502 |
| intestine | 64% | 289.03 | 615 / 966 | 49% | 2.31 | 256 / 527 |
| kidney | 92% | 338.85 | 82 / 89 | 20% | 0.73 | 181 / 901 |
| lung | 83% | 681.34 | 477 / 578 | 19% | 0.59 | 223 / 1155 |
| skin | 91% | 1008.59 | 1639 / 1809 | 10% | 4.10 | 48 / 472 |
| stomach | 55% | 273.12 | 199 / 359 | 38% | 1.99 | 109 / 286 |
| esophagus | 69% | 340.87 | 991 / 1445 | 18% | 0.59 | 33 / 183 |
| spleen | 78% | 348.42 | 189 / 241 | 0% | 0 | 0 / 0 |
| uterus | 54% | 157.55 | 91 / 170 | 16% | 0.59 | 75 / 459 |
| bladder | 38% | 75.95 | 8 / 21 | 31% | 2.46 | 155 / 504 |
| peripheral blood | 68% | 315.81 | 630 / 929 | 0% | 0 | 0 / 0 |
| liver | 61% | 288.17 | 138 / 226 | 6% | 0.21 | 23 / 406 |
| brain | 53% | 272.77 | 1398 / 2642 | 14% | 0.38 | 97 / 705 |
| heart | 63% | 295.54 | 544 / 861 | 0% | 0 | 0 / 0 |
| ovary | 54% | 189.80 | 98 / 180 | 6% | 0.16 | 27 / 430 |
| pancreas | 52% | 797.67 | 169 / 328 | 6% | 0.81 | 10 / 178 |
| adipose | 53% | 250.57 | 633 / 1204 | 0% | 0 | 0 / 0 |
| breast | 47% | 224.10 | 218 / 459 | 4% | 0.13 | 44 / 1118 |
| blood vessel | 48% | 235.90 | 643 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 43% | 241.24 | 344 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 0.68 | 9 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 2.48 | 13 / 45 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.04 | 3 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0042446 | Biological process | hormone biosynthetic process |
| GO_0031641 | Biological process | regulation of myelination |
| GO_0030878 | Biological process | thyroid gland development |
| GO_0006590 | Biological process | thyroid hormone generation |
| GO_0015705 | Biological process | iodide transport |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005179 | Molecular function | hormone activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TG |
| Protein name | Thyroglobulin Thyroglobulin (Tg) TG protein |
| Synonyms | |
| Description | FUNCTION: Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) . The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen . Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream . One dimer produces 7 thyroid hormone molecules . . |
| Accessions | ENST00000220616.9 [P01266-1] ENST00000521107.1 A1L1A0 A0A3Q9NB19 ENST00000522797.1 H0YBL4 H0YBR7 E5RG33 E7EVM0 A0A411DFD1 A0A5P9KEK2 ENST00000519543.5 ENST00000523901.1 H0YB42 ENST00000519178.5 ENST00000523756.5 H0YBJ2 A0A3G5AJ89 H0YBY1 B2RU26 A0A5P9KIV3 Q9NYM1 H0YBQ6 H0YBC5 P01266 ENST00000518505.1 ENST00000518108.1 ENST00000518058.1 |
