SMPD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001778Biological processplasma membrane repair
GO_0006685Biological processsphingomyelin catabolic process
GO_0006684Biological processsphingomyelin metabolic process
GO_0034644Biological processcellular response to UV
GO_0010212Biological processresponse to ionizing radiation
GO_0007165Biological processsignal transduction
GO_0009615Biological processresponse to virus
GO_0008203Biological processcholesterol metabolic process
GO_0046598Biological processpositive regulation of viral entry into host cell
GO_0045807Biological processpositive regulation of endocytosis
GO_0070555Biological processresponse to interleukin-1
GO_0023021Biological processtermination of signal transduction
GO_0034612Biological processresponse to tumor necrosis factor
GO_0046513Biological processceramide biosynthetic process
GO_0071277Biological processcellular response to calcium ion
GO_0046479Biological processglycosphingolipid catabolic process
GO_0042060Biological processwound healing
GO_0042220Biological processresponse to cocaine
GO_0046718Biological processsymbiont entry into host cell
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0043065Biological processpositive regulation of apoptotic process
GO_0034340Biological processresponse to type I interferon
GO_0007399Biological processnervous system development
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0042599Cellular componentlamellar body
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0036019Cellular componentendolysosome
GO_0043202Cellular componentlysosomal lumen
GO_0005768Cellular componentendosome
GO_0004767Molecular functionsphingomyelin phosphodiesterase activity
GO_0016798Molecular functionhydrolase activity, acting on glycosyl bonds
GO_0008270Molecular functionzinc ion binding
GO_0034480Molecular functionphosphatidylcholine phospholipase C activity
GO_0005515Molecular functionprotein binding
GO_0061750Molecular functionacid sphingomyelin phosphodiesterase activity

IV. Literature review

[source]
Gene nameSMPD1
Protein nameSphingomyelin phosphodiesterase
Sphingomyelin phosphodiesterase 1 isoform 7 (EC 3.1.4.12)
Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (aSMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form]
Sphingomyelin phosphodiesterase 1 isoform 6 (EC 3.1.4.12)
Sphingomyelin phosphodiesterase 1
Sphingomyelin phosphodiesterase (EC 3.1.4.12)
SMPD1 protein
SynonymsASM
hCG_24080
DescriptionFUNCTION: Converts sphingomyelin to ceramide . Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly . However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form . .; FUNCTION: In the lysosomes, converts sphingomyelin to ceramide . Plays an important role in the export of cholesterol from the intraendolysosomal membranes . Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol . Modulates stress-induced apoptosis through the production of ceramide . .; FUNCTION: When secreted, modulates cell signaling with its ability to reorganize the plasma membrane by converting sphingomyelin to ceramide . Secreted form is increased in response to stress and inflammatory mediators such as IL1B, IFNG or TNF as well as upon infection with bacteria and viruses . Produces the release of ceramide in the outer leaflet of the plasma membrane playing a central role in host defense . Ceramide reorganizes these rafts into larger signaling platforms that are required to internalize P. aeruginosa, induce apoptosis and regulate the cytokine response in infected cells . In wounded cells, the lysosomal form is released extracellularly in the presence of Ca(2+) and promotes endocytosis and plasma membrane repair . .; FUNCTION: [Sphingomyelin phosphodiesterase, processed form]: This form is generated following cleavage by CASP7 in the extracellular milieu in response to bacterial infection . It shows increased ability to convert sphingomyelin to ceramide and promotes plasma membrane repair (By similarity). Plasma membrane repair by ceramide counteracts the action of gasdermin-D (GSDMD) perforin (PRF1) pores that are formed in response to bacterial infection (By similarity). .; FUNCTION: (Microbial infection) Secretion is activated by bacteria such as P. aeruginos, N. gonorrhoeae and others, this activation results in the release of ceramide in the outer leaflet of the plasma membrane which facilitates the infection. .; FUNCTION: (Microbial infection) Secretion is activated by human coronaviruses SARS-CoV and SARS-CoV-2 as well as Zaire ebolavirus, this activation results in the release of ceramide in the outer leaflet of the plasma membrane which facilitates the infection. .; FUNCTION: [Isoform 2]: Lacks residues that bind the cofactor Zn(2+) and has no enzyme activity. .; FUNCTION: [Isoform 3]: Lacks residues that bind the cofactor Zn(2+) and has no enzyme activity. .

FUNCTION: Converts sphingomyelin to ceramide. .

FUNCTION: Converts sphingomyelin to ceramide. .

AccessionsE9LUE8
ENST00000533123.5
ENST00000534405.5
E9PPK6
Q8IUN0
ENST00000530395.1
Q15495
Q15496
ENST00000531303.5
P17405
ENST00000527275.5 [P17405-4]
ENST00000526280.1
E9LUE7
ENST00000342245.9 [P17405-1]
E9PL59
G3V1E1
H0YEP5
E9PQT3
Q8TEY3
E9LUE9
Q15494
E9LUE6