NMB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NMB at tissue level.

III. Associated gene sets

GO_0046888Biological processnegative regulation of hormone secretion
GO_0007218Biological processneuropeptide signaling pathway
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0007165Biological processsignal transduction
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0160024Biological processLeydig cell proliferation
GO_0090290Biological processpositive regulation of osteoclast proliferation
GO_1903942Biological processpositive regulation of respiratory gaseous exchange
GO_0007267Biological processcell-cell signaling
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_2000845Biological processpositive regulation of testosterone secretion
GO_0160023Biological processsneeze reflex
GO_0046887Biological processpositive regulation of hormone secretion
GO_0160025Biological processsensory perception of itch
GO_0140374Biological processantiviral innate immune response
GO_0050482Biological processarachidonic acid secretion
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0043005Cellular componentneuron projection
GO_0005179Molecular functionhormone activity
GO_0031710Molecular functionneuromedin B receptor binding
GO_0005515Molecular functionprotein binding
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene nameNMB
Protein nameNeuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]
Synonyms
DescriptionFUNCTION: Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 . Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). .

AccessionsENST00000708236.1 [P08949-2]
ENST00000394588.3 [P08949-2]
ENST00000708237.1 [P08949-1]
ENST00000360476.8 [P08949-1]
P08949