Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 24 studies | 24% ± 11% | |
| classical monocyte | 21 studies | 32% ± 16% | |
| mast cell | 17 studies | 22% ± 6% | |
| astrocyte | 16 studies | 32% ± 14% | |
| monocyte | 12 studies | 24% ± 7% | |
| fibroblast | 11 studies | 23% ± 5% | |
| non-classical monocyte | 10 studies | 22% ± 5% | |
| microglial cell | 10 studies | 28% ± 10% | |
| neutrophil | 9 studies | 24% ± 8% | |
| oligodendrocyte precursor cell | 9 studies | 26% ± 11% | |
| adipocyte | 9 studies | 47% ± 7% | |
| glutamatergic neuron | 8 studies | 34% ± 21% | |
| GABAergic neuron | 7 studies | 32% ± 16% | |
| myeloid cell | 7 studies | 34% ± 23% | |
| alveolar macrophage | 7 studies | 25% ± 6% | |
| conventional dendritic cell | 6 studies | 19% ± 3% | |
| basal cell | 6 studies | 24% ± 6% | |
| retinal cone cell | 5 studies | 28% ± 10% | |
| dendritic cell | 5 studies | 20% ± 4% | |
| CD4-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
| neuron | 4 studies | 28% ± 10% | |
| endothelial cell | 4 studies | 22% ± 5% | |
| naive B cell | 4 studies | 22% ± 10% | |
| epithelial cell | 4 studies | 37% ± 17% | |
| ciliated cell | 4 studies | 27% ± 17% | |
| melanocyte | 4 studies | 39% ± 8% | |
| hepatocyte | 4 studies | 43% ± 23% | |
| abnormal cell | 4 studies | 28% ± 5% | |
| oligodendrocyte | 4 studies | 26% ± 7% | |
| mononuclear phagocyte | 3 studies | 25% ± 7% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 29% ± 4% | |
| B cell | 3 studies | 19% ± 3% | |
| club cell | 3 studies | 22% ± 7% | |
| CD4-positive helper T cell | 3 studies | 27% ± 11% | |
| Schwann cell | 3 studies | 52% ± 2% | |
| keratinocyte | 3 studies | 22% ± 4% | |
| natural killer cell | 3 studies | 22% ± 4% | |
| pancreatic A cell | 3 studies | 24% ± 7% | |
| ependymal cell | 3 studies | 42% ± 21% | |
| hematopoietic precursor cell | 3 studies | 34% ± 13% | |
| leukocyte | 3 studies | 19% ± 0% | |
| interneuron | 3 studies | 37% ± 16% | |
| myoepithelial cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 4425.08 | 2614 / 2642 | 100% | 45.83 | 702 / 705 |
| adrenal gland | 100% | 6453.22 | 258 / 258 | 98% | 42.02 | 226 / 230 |
| prostate | 99% | 5977.23 | 242 / 245 | 99% | 44.89 | 498 / 502 |
| skin | 100% | 7339.02 | 1806 / 1809 | 97% | 39.96 | 457 / 472 |
| intestine | 99% | 3673.58 | 954 / 966 | 96% | 37.37 | 504 / 527 |
| ovary | 100% | 7453.43 | 180 / 180 | 94% | 27.16 | 405 / 430 |
| liver | 98% | 4655.81 | 221 / 226 | 94% | 32.69 | 382 / 406 |
| stomach | 90% | 2529.18 | 323 / 359 | 91% | 37.87 | 261 / 286 |
| thymus | 96% | 2504.91 | 625 / 653 | 85% | 17.88 | 513 / 605 |
| lung | 97% | 4943.97 | 558 / 578 | 83% | 22.99 | 956 / 1155 |
| esophagus | 89% | 4068.62 | 1279 / 1445 | 89% | 41.80 | 163 / 183 |
| breast | 100% | 8253.14 | 458 / 459 | 75% | 16.89 | 836 / 1118 |
| uterus | 97% | 4938.34 | 165 / 170 | 54% | 10.16 | 250 / 459 |
| bladder | 90% | 2905.62 | 19 / 21 | 57% | 12.15 | 287 / 504 |
| pancreas | 39% | 626.05 | 127 / 328 | 92% | 18.45 | 163 / 178 |
| kidney | 49% | 867.72 | 44 / 89 | 69% | 14.61 | 621 / 901 |
| eye | 0% | 0 | 0 / 0 | 100% | 49.80 | 80 / 80 |
| adipose | 100% | 7244.13 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5980.49 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 97% | 5003.39 | 777 / 803 | 0% | 0 | 0 / 0 |
| heart | 87% | 3066.59 | 746 / 861 | 0% | 0 | 0 / 0 |
| spleen | 81% | 2197.24 | 195 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 57% | 2162.43 | 529 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 38% | 6.78 | 17 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.87 | 3 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901653 | Biological process | cellular response to peptide |
| GO_0030879 | Biological process | mammary gland development |
| GO_0071333 | Biological process | cellular response to glucose stimulus |
| GO_0046326 | Biological process | positive regulation of glucose import |
| GO_0032869 | Biological process | cellular response to insulin stimulus |
| GO_0010748 | Biological process | negative regulation of long-chain fatty acid import across plasma membrane |
| GO_0009749 | Biological process | response to glucose |
| GO_0032000 | Biological process | positive regulation of fatty acid beta-oxidation |
| GO_0010631 | Biological process | epithelial cell migration |
| GO_0007165 | Biological process | signal transduction |
| GO_0002903 | Biological process | negative regulation of B cell apoptotic process |
| GO_0019216 | Biological process | regulation of lipid metabolic process |
| GO_0032024 | Biological process | positive regulation of insulin secretion |
| GO_0045725 | Biological process | positive regulation of glycogen biosynthetic process |
| GO_0002053 | Biological process | positive regulation of mesenchymal cell proliferation |
| GO_0033673 | Biological process | negative regulation of kinase activity |
| GO_0008286 | Biological process | insulin receptor signaling pathway |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0010907 | Biological process | positive regulation of glucose metabolic process |
| GO_0007420 | Biological process | brain development |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_1904692 | Biological process | positive regulation of type B pancreatic cell proliferation |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0044342 | Biological process | type B pancreatic cell proliferation |
| GO_0006006 | Biological process | glucose metabolic process |
| GO_0010634 | Biological process | positive regulation of epithelial cell migration |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0141038 | Molecular function | phosphatidylinositol 3-kinase activator activity |
| GO_0005158 | Molecular function | insulin receptor binding |
| GO_0043548 | Molecular function | phosphatidylinositol 3-kinase binding |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0019903 | Molecular function | protein phosphatase binding |
| GO_0071889 | Molecular function | 14-3-3 protein binding |
| GO_0005068 | Molecular function | transmembrane receptor protein tyrosine kinase adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IRS2 |
| Protein name | Insulin receptor substrate 2 insertion mutant Insulin receptor substrate-2 Insulin receptor substrate 2 (IRS-2) Alternative protein IRS2 |
| Synonyms | |
| Description | FUNCTION: May mediate the control of various cellular processes by insulin. |
| Accessions | L0R5B5 L8ECA6 Q9UP29 Q96RG5 Q96RG4 ENST00000375856.5 Q9Y4H2 |