GRB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0031623Biological processreceptor internalization
GO_0042552Biological processmyelination
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0050853Biological processB cell receptor signaling pathway
GO_0035987Biological processendodermal cell differentiation
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0030036Biological processactin cytoskeleton organization
GO_0008286Biological processinsulin receptor signaling pathway
GO_0014044Biological processSchwann cell development
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0060670Biological processbranching involved in labyrinthine layer morphogenesis
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0043408Biological processregulation of MAPK cascade
GO_0071479Biological processcellular response to ionizing radiation
GO_0042770Biological processsignal transduction in response to DNA damage
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0012506Cellular componentvesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005911Cellular componentcell-cell junction
GO_0070436Cellular componentGrb2-EGFR complex
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0008180Cellular componentCOP9 signalosome
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0046875Molecular functionephrin receptor binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0005068Molecular functiontransmembrane receptor protein tyrosine kinase adaptor activity
GO_0005091Molecular functionguanyl-nucleotide exchange factor adaptor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0005168Molecular functionneurotrophin TRKA receptor binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameGRB2
Protein nameGrowth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Growth factor receptor-bound protein 2 (cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA)
GRB2 protein
Growth factor receptor bound protein 2
SynonymsASH
hCG_27179
DescriptionFUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. .; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. .

AccessionsJ3QLF6
ENST00000581959.1
J3KT38
ENST00000392563.5 [P62993-2]
ENST00000316615.9 [P62993-2]
ENST00000582582.1
J3QRL5
ENST00000648046.1 [P62993-1]
Q6ICN0
B0LPF3
P62993
ENST00000578961.5
ENST00000392564.5 [P62993-1]
ENST00000316804.10 [P62993-1]
ENST00000392562.5 [P62993-1]