ADCY8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0051260Biological processprotein homooligomerization
GO_0071333Biological processcellular response to glucose stimulus
GO_0050796Biological processregulation of insulin secretion
GO_0032793Biological processpositive regulation of CREB transcription factor activity
GO_0006171Biological processcAMP biosynthetic process
GO_0031915Biological processpositive regulation of synaptic plasticity
GO_0007611Biological processlearning or memory
GO_0007616Biological processlong-term memory
GO_0007165Biological processsignal transduction
GO_1900454Biological processpositive regulation of long-term synaptic depression
GO_0071315Biological processcellular response to morphine
GO_0071277Biological processcellular response to calcium ion
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0051259Biological processprotein complex oligomerization
GO_0035556Biological processintracellular signal transduction
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_1904322Biological processcellular response to forskolin
GO_0071377Biological processcellular response to glucagon stimulus
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_0007626Biological processlocomotory behavior
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007613Biological processmemory
GO_0034199Biological processactivation of protein kinase A activity
GO_0080135Biological processregulation of cellular response to stress
GO_0150076Biological processneuroinflammatory response
GO_0038003Biological processG protein-coupled opioid receptor signaling pathway
GO_0042593Biological processglucose homeostasis
GO_0010255Biological processglucose mediated signaling pathway
GO_0016324Cellular componentapical plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0032809Cellular componentneuronal cell body membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0044853Cellular componentplasma membrane raft
GO_0015629Cellular componentactin cytoskeleton
GO_0048786Cellular componentpresynaptic active zone
GO_0014069Cellular componentpostsynaptic density
GO_0005905Cellular componentclathrin-coated pit
GO_0030424Cellular componentaxon
GO_0060076Cellular componentexcitatory synapse
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0005901Cellular componentcaveola
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008294Molecular functioncalcium- and calmodulin-responsive adenylate cyclase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0004016Molecular functionadenylate cyclase activity
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0003779Molecular functionactin binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005516Molecular functioncalmodulin binding
GO_0046983Molecular functionprotein dimerization activity

IV. Literature review

[source]
Gene nameADCY8
Protein nameadenylate cyclase (EC 4.6.1.1)
Adenylate cyclase type 8 (EC 4.6.1.1)
Adenylate cyclase type 8 (EC 4.6.1.1) (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (AC8) (Ca(2+)/calmodulin-activated adenylyl cyclase)
Alternative protein ADCY8
SynonymsHEL-S-172mP
hCG_2008967
DescriptionFUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. .

FUNCTION: Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. .

FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. .

FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. .

AccessionsENST00000377928.7
E7EVL1
P40145
A0A0K0K1K3
L8E7I7
E5RFR2
ENST00000522949.1
ENST00000286355.10
Q4F7X0