DLG5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	10 studies	34% ± 13%	Explore
ciliated cell	6 studies	26% ± 11%	Explore
basal cell	6 studies	30% ± 15%	Explore
neuron	5 studies	30% ± 14%	Explore
epithelial cell	5 studies	38% ± 20%	Explore
retina horizontal cell	5 studies	40% ± 10%	Explore
Mueller cell	5 studies	37% ± 22%	Explore
endothelial cell	4 studies	30% ± 16%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 9%	Explore
smooth muscle cell	4 studies	18% ± 2%	Explore
interneuron	3 studies	34% ± 17%	Explore
placental villous trophoblast	3 studies	26% ± 3%	Explore
amacrine cell	3 studies	30% ± 12%	Explore
fibroblast	3 studies	21% ± 5%	Explore
adipocyte	3 studies	21% ± 5%	Explore
GABAergic neuron	3 studies	34% ± 13%	Explore
glutamatergic neuron	3 studies	37% ± 14%	Explore
oligodendrocyte	3 studies	19% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	30% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5306.32	1439 / 1445	99%	35.42	182 / 183
breast	100%	5793.23	458 / 459	96%	36.32	1069 / 1118
intestine	100%	4720.73	962 / 966	94%	14.80	497 / 527
lung	98%	2120.43	565 / 578	94%	20.17	1084 / 1155
ovary	100%	4716.46	180 / 180	91%	19.77	393 / 430
prostate	100%	8223.55	245 / 245	91%	23.05	458 / 502
stomach	97%	3300.85	349 / 359	93%	17.31	266 / 286
thymus	100%	6911.35	652 / 653	90%	24.62	543 / 605
bladder	100%	4701.52	21 / 21	87%	15.68	439 / 504
adrenal gland	100%	11494.49	258 / 258	87%	18.21	200 / 230
uterus	100%	5291.17	170 / 170	86%	22.80	397 / 459
pancreas	90%	1420.96	295 / 328	90%	15.58	160 / 178
brain	82%	1379.67	2170 / 2642	95%	31.47	672 / 705
skin	100%	6913.95	1804 / 1809	65%	7.45	308 / 472
kidney	90%	1663.55	80 / 89	70%	7.83	628 / 901
adipose	100%	2741.13	1200 / 1204	0%	0	0 / 0
blood vessel	99%	3672.57	1328 / 1335	0%	0	0 / 0
muscle	99%	4040.98	798 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	32.27	42 / 45
heart	70%	983.68	599 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	60%	4.93	48 / 80
liver	14%	150.47	31 / 226	36%	4.08	147 / 406
spleen	43%	544.36	104 / 241	0%	0	0 / 0
peripheral blood	7%	88.20	62 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0099173	Biological process	postsynapse organization
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0030011	Biological process	maintenance of cell polarity
GO_0072205	Biological process	metanephric collecting duct development
GO_0007165	Biological process	signal transduction
GO_0060441	Biological process	epithelial tube branching involved in lung morphogenesis
GO_0045176	Biological process	apical protein localization
GO_0045186	Biological process	zonula adherens assembly
GO_0065003	Biological process	protein-containing complex assembly
GO_0071896	Biological process	protein localization to adherens junction
GO_0045880	Biological process	positive regulation of smoothened signaling pathway
GO_0035332	Biological process	positive regulation of hippo signaling
GO_0035556	Biological process	intracellular signal transduction
GO_0042981	Biological process	regulation of apoptotic process
GO_0060563	Biological process	neuroepithelial cell differentiation
GO_0042130	Biological process	negative regulation of T cell proliferation
GO_0060999	Biological process	positive regulation of dendritic spine development
GO_0030336	Biological process	negative regulation of cell migration
GO_0098609	Biological process	cell-cell adhesion
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0045197	Biological process	establishment or maintenance of epithelial cell apical/basal polarity
GO_0030901	Biological process	midbrain development
GO_0030859	Biological process	polarized epithelial cell differentiation
GO_0035331	Biological process	negative regulation of hippo signaling
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0005912	Cellular component	adherens junction
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0030054	Cellular component	cell junction
GO_0036064	Cellular component	ciliary basal body
GO_0008013	Molecular function	beta-catenin binding
GO_0030159	Molecular function	signaling receptor complex adaptor activity
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DLG5
Protein name	Disks large homolog 5 Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Discs large MAGUK scaffold protein 5 (Disks large homolog 5) Alternative protein DLG5
Synonyms	KIAA0583 PDLG
Description	FUNCTION: Acts as a regulator of the Hippo signaling pathway . Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 . Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion . Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). .
Accessions	Q8TDM6 ENST00000424842.5 ENST00000614211.2 [Q8TDM6-1] A0A0A0MSL1 R4GMQ2 ENST00000632221.1 A0A0J9YYG8 L8EAB8 ENST00000468332.6 ENST00000633108.1 ENST00000632417.1 ENST00000372391.7 [Q8TDM6-1]

DLG5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review