POMC report

I. Expression across cell types

Insufficient scRNA-seq data for expression of POMC at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POMC at tissue level.

III. Associated gene sets

GO_0070873Biological processregulation of glycogen metabolic process
GO_0007218Biological processneuropeptide signaling pathway
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0019722Biological processcalcium-mediated signaling
GO_0007165Biological processsignal transduction
GO_0008217Biological processregulation of blood pressure
GO_2000852Biological processregulation of corticosterone secretion
GO_0032098Biological processregulation of appetite
GO_0007267Biological processcell-cell signaling
GO_1990680Biological processresponse to melanocyte-stimulating hormone
GO_0033059Biological processcellular pigmentation
GO_0140668Biological processpositive regulation of oxytocin production
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0106071Biological processpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0042593Biological processglucose homeostasis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0034774Cellular componentsecretory granule lumen
GO_0005737Cellular componentcytoplasm
GO_0030141Cellular componentsecretory granule
GO_0070996Molecular functiontype 1 melanocortin receptor binding
GO_0031781Molecular functiontype 3 melanocortin receptor binding
GO_0005179Molecular functionhormone activity
GO_0005102Molecular functionsignaling receptor binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0031782Molecular functiontype 4 melanocortin receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOMC
Protein namePro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]
Proopiomelanocortin
Pro-opiomelanocortin
Pro-opiomelanocortin (Corticotropin-lipotropin)
Synonymsproopiomelanocortin/
DescriptionFUNCTION: [Corticotropin]: Stimulates the adrenal glands to release cortisol.; FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.; FUNCTION: [Met-enkephalin]: Endogenous opiate.

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

FUNCTION: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. .; FUNCTION: Endogenous opiate. .; FUNCTION: Endogenous orexigenic opiate. .; FUNCTION: Stimulates the adrenal glands to release cortisol. .

AccessionsK7QX47
K7RMD8
K7R8V7
ENST00000449220.1
K7QX44
K7RME8
ENST00000395826.7
K7R8V2
K7QZC2
K7QZC9
Q6FHC8
Q53WY7
ENST00000380794.5
K7R8W0
Q6LDP0
P01189
E9PHK5
K7R2J5
ENST00000405623.5
K7R2I7
K7RMF2
K7QX41
ENST00000264708.7
K7QZD2
K7QX51