PTPRT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	12 studies	63% ± 14%	Explore
glutamatergic neuron	11 studies	61% ± 21%	Explore
ciliated cell	10 studies	46% ± 23%	Explore
GABAergic neuron	10 studies	43% ± 16%	Explore
astrocyte	6 studies	42% ± 27%	Explore
interneuron	6 studies	41% ± 17%	Explore
neuron	4 studies	35% ± 11%	Explore
endothelial cell	4 studies	40% ± 16%	Explore
GABAergic interneuron	3 studies	37% ± 9%	Explore
GABAergic amacrine cell	3 studies	25% ± 6%	Explore
ON-bipolar cell	3 studies	43% ± 19%	Explore
glycinergic amacrine cell	3 studies	51% ± 10%	Explore
rod bipolar cell	3 studies	56% ± 25%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	37% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	2436.88	2553 / 2642	77%	14.31	541 / 705
breast	71%	387.73	324 / 459	65%	19.34	727 / 1118
prostate	41%	100.09	100 / 245	57%	6.59	285 / 502
lung	51%	325.79	293 / 578	16%	1.26	181 / 1155
pancreas	46%	130.63	150 / 328	6%	1.25	10 / 178
stomach	47%	92.62	169 / 359	1%	0.04	4 / 286
skin	48%	113.38	866 / 1809	0%	0.16	2 / 472
spleen	27%	46.03	65 / 241	0%	0	0 / 0
intestine	25%	50.11	244 / 966	2%	0.11	8 / 527
adipose	26%	56.19	314 / 1204	0%	0	0 / 0
ovary	3%	3.66	5 / 180	16%	1.92	69 / 430
thymus	3%	4.38	17 / 653	15%	2.67	88 / 605
uterus	4%	54.98	6 / 170	7%	0.45	33 / 459
adrenal gland	3%	5.15	8 / 258	7%	0.93	17 / 230
liver	7%	7.89	15 / 226	2%	0.12	10 / 406
esophagus	1%	1.67	15 / 1445	8%	0.43	14 / 183
bladder	5%	12.48	1 / 21	4%	0.41	18 / 504
heart	6%	10.95	55 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	4%	0.21	2 / 45
lymph node	0%	0	0 / 0	3%	0.08	1 / 29
blood vessel	2%	3.20	25 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.06	1 / 80
kidney	0%	0	0 / 89	1%	0.10	5 / 901
peripheral blood	0%	0.80	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006470	Biological process	protein dephosphorylation
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0007165	Biological process	signal transduction
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0007155	Biological process	cell adhesion
GO_0050807	Biological process	regulation of synapse organization
GO_1904893	Biological process	negative regulation of receptor signaling pathway via STAT
GO_0007156	Biological process	homophilic cell adhesion via plasma membrane adhesion molecules
GO_0030336	Biological process	negative regulation of cell migration
GO_1990264	Biological process	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO_0071354	Biological process	cellular response to interleukin-6
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0009986	Cellular component	cell surface
GO_0070097	Molecular function	delta-catenin binding
GO_0005001	Molecular function	transmembrane receptor protein tyrosine phosphatase activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0045294	Molecular function	alpha-catenin binding
GO_0019903	Molecular function	protein phosphatase binding
GO_0045296	Molecular function	cadherin binding
GO_0016790	Molecular function	thiolester hydrolase activity
GO_0097677	Molecular function	STAT family protein binding
GO_0008013	Molecular function	beta-catenin binding
GO_0051393	Molecular function	alpha-actinin binding
GO_0045295	Molecular function	gamma-catenin binding
GO_0005515	Molecular function	protein binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	PTPRT
Protein name	Alternative protein PTPRT protein-tyrosine-phosphatase (EC 3.1.3.48) Protein tyrosine phosphatase receptor type T Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)
Synonyms	KIAA0283
Description	FUNCTION: May be involved in both signal transduction and cellular adhesion in the CNS.
Accessions	O14522 ENST00000373187.6 [O14522-3] ENST00000373193.7 [O14522-1] ENST00000373198.8 A0A075B6H0 B1AJR6 B1AJR8 B1AJS0 ENST00000373184.5 A0A087X1J1 L8ECM4 ENST00000373201.5 ENST00000356100.6 ENST00000373190.5 ENST00000617474.1 B1AJR9

PTPRT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review