Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 32% ± 15% | |
fibroblast | 16 studies | 35% ± 12% | |
macrophage | 14 studies | 27% ± 14% | |
ciliated cell | 14 studies | 34% ± 12% | |
smooth muscle cell | 12 studies | 22% ± 7% | |
epithelial cell | 12 studies | 41% ± 20% | |
astrocyte | 10 studies | 27% ± 12% | |
basal cell | 9 studies | 42% ± 21% | |
myeloid cell | 8 studies | 29% ± 10% | |
adipocyte | 8 studies | 30% ± 11% | |
type I pneumocyte | 6 studies | 33% ± 18% | |
type II pneumocyte | 6 studies | 38% ± 21% | |
non-classical monocyte | 6 studies | 24% ± 5% | |
GABAergic neuron | 6 studies | 38% ± 20% | |
glutamatergic neuron | 6 studies | 44% ± 22% | |
club cell | 6 studies | 23% ± 5% | |
mesothelial cell | 6 studies | 30% ± 6% | |
secretory cell | 6 studies | 37% ± 12% | |
pericyte | 6 studies | 24% ± 5% | |
classical monocyte | 5 studies | 31% ± 3% | |
adventitial cell | 5 studies | 23% ± 6% | |
cardiac muscle cell | 5 studies | 32% ± 8% | |
dendritic cell | 5 studies | 28% ± 11% | |
endothelial cell of vascular tree | 5 studies | 41% ± 20% | |
monocyte | 5 studies | 31% ± 19% | |
mast cell | 4 studies | 23% ± 7% | |
natural killer cell | 4 studies | 19% ± 3% | |
endothelial cell of lymphatic vessel | 4 studies | 42% ± 24% | |
deuterosomal cell | 4 studies | 26% ± 6% | |
squamous epithelial cell | 4 studies | 42% ± 21% | |
conventional dendritic cell | 4 studies | 38% ± 9% | |
microglial cell | 4 studies | 25% ± 6% | |
retinal pigment epithelial cell | 4 studies | 33% ± 11% | |
lymphocyte | 4 studies | 18% ± 3% | |
luminal cell of prostate epithelium | 4 studies | 27% ± 7% | |
oligodendrocyte | 4 studies | 24% ± 5% | |
alveolar macrophage | 4 studies | 29% ± 16% | |
neuron | 4 studies | 44% ± 23% | |
ionocyte | 3 studies | 23% ± 6% | |
respiratory goblet cell | 3 studies | 27% ± 9% | |
hematopoietic precursor cell | 3 studies | 25% ± 5% | |
neutrophil | 3 studies | 21% ± 6% | |
muscle cell | 3 studies | 30% ± 20% | |
oligodendrocyte precursor cell | 3 studies | 24% ± 2% | |
acinar cell | 3 studies | 44% ± 24% | |
pancreatic ductal cell | 3 studies | 52% ± 18% | |
abnormal cell | 3 studies | 42% ± 32% | |
connective tissue cell | 3 studies | 34% ± 10% | |
ependymal cell | 3 studies | 28% ± 12% | |
transit amplifying cell | 3 studies | 42% ± 32% | |
interneuron | 3 studies | 40% ± 19% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 10 studies | 30% ± 16% | |
lung | 7 studies | 34% ± 14% | |
peripheral blood | 5 studies | 19% ± 2% | |
pancreas | 4 studies | 29% ± 15% | |
heart | 4 studies | 24% ± 5% | |
liver | 4 studies | 38% ± 28% | |
prostate | 4 studies | 41% ± 10% | |
intestine | 3 studies | 16% ± 1% | |
adipose | 3 studies | 36% ± 24% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 11922.63 | 577 / 578 | 100% | 196.03 | 1152 / 1155 |
intestine | 100% | 7711.10 | 965 / 966 | 99% | 62.04 | 523 / 527 |
ovary | 99% | 5827.77 | 179 / 180 | 99% | 42.59 | 427 / 430 |
adrenal gland | 100% | 26642.02 | 258 / 258 | 97% | 75.95 | 224 / 230 |
breast | 99% | 4213.19 | 455 / 459 | 98% | 52.53 | 1093 / 1118 |
stomach | 96% | 7535.77 | 346 / 359 | 100% | 58.80 | 285 / 286 |
esophagus | 94% | 8796.17 | 1358 / 1445 | 99% | 104.79 | 181 / 183 |
prostate | 96% | 7242.04 | 235 / 245 | 96% | 42.21 | 484 / 502 |
uterus | 99% | 6731.35 | 169 / 170 | 92% | 52.91 | 423 / 459 |
kidney | 94% | 5068.55 | 84 / 89 | 95% | 63.86 | 858 / 901 |
bladder | 100% | 25521.81 | 21 / 21 | 88% | 65.09 | 441 / 504 |
thymus | 99% | 6103.34 | 644 / 653 | 89% | 29.36 | 536 / 605 |
brain | 85% | 2718.66 | 2244 / 2642 | 100% | 51.34 | 704 / 705 |
liver | 86% | 3523.46 | 195 / 226 | 94% | 79.98 | 381 / 406 |
skin | 75% | 14249.38 | 1360 / 1809 | 96% | 60.11 | 455 / 472 |
pancreas | 43% | 1063.67 | 141 / 328 | 98% | 47.43 | 174 / 178 |
ureter | 0% | 0 | 0 / 0 | 100% | 22.93 | 1 / 1 |
blood vessel | 100% | 11238.77 | 1333 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 6809.50 | 1202 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 7175.68 | 799 / 803 | 0% | 0 | 0 / 0 |
spleen | 99% | 4841.95 | 239 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 42.42 | 42 / 45 |
heart | 91% | 7877.28 | 781 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 46.63 | 26 / 29 |
eye | 0% | 0 | 0 / 0 | 84% | 29.34 | 67 / 80 |
peripheral blood | 71% | 3510.48 | 656 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0045454 | Biological process | cell redox homeostasis |
GO_0001707 | Biological process | mesoderm formation |
GO_0008283 | Biological process | cell population proliferation |
GO_0098869 | Biological process | cellular oxidant detoxification |
GO_0001650 | Cellular component | fibrillar center |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0071949 | Molecular function | FAD binding |
GO_0050137 | Molecular function | NADPH peroxidase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0004791 | Molecular function | thioredoxin-disulfide reductase (NADPH) activity |
Gene name | TXNRD1 |
Protein name | Thioredoxin reductase 1 Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) Thioredoxin reductase 1, cytoplasmic (EC 1.11.1.2) (EC 1.8.1.9) (Peroxidase TXNRD1) (Thioredoxin reductase TR1) |
Synonyms | GRIM12 KDRF |
Description | FUNCTION: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form . Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) . .; FUNCTION: [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. .; FUNCTION: [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. .; FUNCTION: [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only . Mediates cell death induced by a combination of interferon-beta and retinoic acid . . |
Accessions | ENST00000531691.5 E9PIR7 ENST00000529784.5 ENST00000527335.5 ENST00000526580.5 A0A182DWI3 ENST00000526390.5 [Q16881-2] A0A0B4J225 ENST00000531689.5 Q16881 E9PKI4 ENST00000526266.5 ENST00000524698.5 [Q16881-5] ENST00000525566.6 [Q16881-1] E9PQI3 ENST00000527688.5 ENST00000526950.1 E9PLT3 ENST00000503506.6 [Q16881-5] E9PIZ5 E9PRI8 ENST00000529751.1 ENST00000526691.5 [Q16881-4] E9PKD3 ENST00000526950.2 [Q16881-6] ENST00000529546.5 [Q16881-7] |