TXNRD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0045454Biological processcell redox homeostasis
GO_0001707Biological processmesoderm formation
GO_0008283Biological processcell population proliferation
GO_0098869Biological processcellular oxidant detoxification
GO_0001650Cellular componentfibrillar center
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0071949Molecular functionFAD binding
GO_0050137Molecular functionNADPH peroxidase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0004791Molecular functionthioredoxin-disulfide reductase (NADPH) activity

IV. Literature review

[source]
Gene nameTXNRD1
Protein nameThioredoxin reductase 1
Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)
Thioredoxin reductase 1, cytoplasmic (EC 1.11.1.2) (EC 1.8.1.9) (Peroxidase TXNRD1) (Thioredoxin reductase TR1)
SynonymsGRIM12
KDRF
DescriptionFUNCTION: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form . Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) . .; FUNCTION: [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. .; FUNCTION: [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. .; FUNCTION: [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only . Mediates cell death induced by a combination of interferon-beta and retinoic acid . .

AccessionsENST00000531691.5
E9PIR7
ENST00000529784.5
ENST00000527335.5
ENST00000526580.5
A0A182DWI3
ENST00000526390.5 [Q16881-2]
A0A0B4J225
ENST00000531689.5
Q16881
E9PKI4
ENST00000526266.5
ENST00000524698.5 [Q16881-5]
ENST00000525566.6 [Q16881-1]
E9PQI3
ENST00000527688.5
ENST00000526950.1
E9PLT3
ENST00000503506.6 [Q16881-5]
E9PIZ5
E9PRI8
ENST00000529751.1
ENST00000526691.5 [Q16881-4]
E9PKD3
ENST00000526950.2 [Q16881-6]
ENST00000529546.5 [Q16881-7]