ASIP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASIP at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0008343Biological processadult feeding behavior
GO_0044725Biological processepigenetic programming in the zygotic pronuclei
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0032438Biological processmelanosome organization
GO_0032402Biological processmelanosome transport
GO_0007267Biological processcell-cell signaling
GO_0048023Biological processpositive regulation of melanin biosynthetic process
GO_0042438Biological processmelanin biosynthetic process
GO_0009755Biological processhormone-mediated signaling pathway
GO_0005615Cellular componentextracellular space
GO_0031779Molecular functionmelanocortin receptor binding
GO_0031782Molecular functiontype 4 melanocortin receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005184Molecular functionneuropeptide hormone activity
GO_0031781Molecular functiontype 3 melanocortin receptor binding

IV. Literature review

[source]
Gene nameASIP
Protein nameAgouti-signaling protein (ASP) (Agouti switch protein)
SynonymsAGTIL
AGTI
ASP
DescriptionFUNCTION: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. .

AccessionsP42127
ENST00000374954.4
ENST00000568305.5