I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 19% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 19% ± 2% |
Insufficient scRNA-seq data for expression of BMP3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 53% | 203.80 | 306 / 578 | 71% | 12.87 | 818 / 1155 |
| intestine | 98% | 2128.63 | 942 / 966 | 24% | 0.95 | 124 / 527 |
| bladder | 52% | 627.48 | 11 / 21 | 61% | 15.85 | 305 / 504 |
| ureter | 0% | 0 | 0 / 0 | 100% | 27.50 | 1 / 1 |
| ovary | 71% | 333.25 | 127 / 180 | 20% | 0.79 | 86 / 430 |
| esophagus | 61% | 748.35 | 882 / 1445 | 21% | 1.20 | 39 / 183 |
| stomach | 44% | 267.31 | 159 / 359 | 24% | 1.21 | 68 / 286 |
| adipose | 54% | 359.03 | 648 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 20% | 41.49 | 49 / 245 | 33% | 0.91 | 168 / 502 |
| breast | 46% | 337.97 | 210 / 459 | 4% | 0.27 | 50 / 1118 |
| uterus | 2% | 5.83 | 4 / 170 | 40% | 6.81 | 182 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 36% | 2.37 | 16 / 45 |
| pancreas | 0% | 0 | 0 / 328 | 29% | 2.58 | 51 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 1.01 | 6 / 29 |
| skin | 18% | 42.48 | 326 / 1809 | 2% | 0.09 | 9 / 472 |
| adrenal gland | 13% | 28.02 | 34 / 258 | 3% | 0.29 | 7 / 230 |
| brain | 12% | 26.07 | 320 / 2642 | 1% | 0.04 | 9 / 705 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.13 | 6 / 80 |
| blood vessel | 5% | 25.57 | 73 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 2% | 4.35 | 15 / 653 | 2% | 0.06 | 14 / 605 |
| kidney | 2% | 3.87 | 2 / 89 | 2% | 0.21 | 21 / 901 |
| peripheral blood | 1% | 2.27 | 9 / 929 | 0% | 0 | 0 / 0 |
| muscle | 1% | 1.46 | 7 / 803 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 0% | 0.02 | 2 / 406 |
| heart | 0% | 0.94 | 4 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0001501 | Biological process | skeletal system development |
| GO_0051216 | Biological process | cartilage development |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0070700 | Molecular function | BMP receptor binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0008083 | Molecular function | growth factor activity |
| Gene name | BMP3 |
| Protein name | Bone morphogenetic protein 3 Bone morphogenetic protein 3 (BMP-3) (Bone morphogenetic protein 3A) (BMP-3A) (Osteogenin) |
| Synonyms | BMP3A |
| Description | FUNCTION: Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification . Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways . . |
| Accessions | D7NTG9 D7NTB8 D7NTK8 D7NTR3 D7NTU0 D7NTV0 D7NTU5 D7NTK7 D7NTK9 D7NU02 D7NTP6 D7NTD1 D7NTU1 D7NT62 ENST00000282701.4 P12645 |
