Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 17 studies | 24% ± 5% | |
classical monocyte | 14 studies | 29% ± 11% | |
monocyte | 12 studies | 31% ± 13% | |
myeloid cell | 8 studies | 23% ± 6% | |
basal cell | 7 studies | 27% ± 9% | |
neutrophil | 6 studies | 47% ± 12% | |
conventional dendritic cell | 6 studies | 21% ± 5% | |
epithelial cell | 6 studies | 43% ± 16% | |
squamous epithelial cell | 4 studies | 63% ± 22% | |
secretory cell | 4 studies | 32% ± 14% | |
keratinocyte | 4 studies | 29% ± 9% | |
dendritic cell | 3 studies | 23% ± 5% | |
mononuclear phagocyte | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 97% | 9204.31 | 219 / 226 | 80% | 42.76 | 325 / 406 |
esophagus | 43% | 50050.16 | 621 / 1445 | 92% | 256.69 | 168 / 183 |
bladder | 38% | 788.62 | 8 / 21 | 84% | 74.43 | 425 / 504 |
lung | 41% | 1115.83 | 237 / 578 | 77% | 57.30 | 894 / 1155 |
ureter | 0% | 0 | 0 / 0 | 100% | 217.23 | 1 / 1 |
stomach | 33% | 818.18 | 118 / 359 | 67% | 37.07 | 191 / 286 |
skin | 72% | 6627.79 | 1296 / 1809 | 27% | 8.86 | 129 / 472 |
tonsil | 0% | 0 | 0 / 0 | 98% | 268.27 | 44 / 45 |
pancreas | 0% | 22.24 | 1 / 328 | 85% | 58.77 | 151 / 178 |
peripheral blood | 79% | 7407.71 | 738 / 929 | 0% | 0 | 0 / 0 |
uterus | 1% | 796.49 | 2 / 170 | 78% | 131.34 | 358 / 459 |
intestine | 8% | 129.11 | 78 / 966 | 64% | 43.82 | 337 / 527 |
ovary | 0% | 0 | 0 / 180 | 67% | 15.68 | 288 / 430 |
breast | 9% | 195.33 | 43 / 459 | 55% | 14.46 | 619 / 1118 |
thymus | 1% | 22.98 | 9 / 653 | 47% | 13.90 | 283 / 605 |
spleen | 47% | 801.08 | 113 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 38% | 18.27 | 11 / 29 |
adipose | 20% | 554.50 | 236 / 1204 | 0% | 0 | 0 / 0 |
prostate | 4% | 49.61 | 9 / 245 | 3% | 0.56 | 13 / 502 |
kidney | 1% | 11.98 | 1 / 89 | 5% | 1.50 | 46 / 901 |
brain | 0% | 11.25 | 12 / 2642 | 5% | 1.26 | 36 / 705 |
adrenal gland | 2% | 36.90 | 5 / 258 | 3% | 0.89 | 7 / 230 |
blood vessel | 2% | 36.88 | 29 / 1335 | 0% | 0 | 0 / 0 |
heart | 1% | 10.15 | 7 / 861 | 0% | 0 | 0 / 0 |
muscle | 0% | 18.40 | 3 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0002437 | Biological process | inflammatory response to antigenic stimulus |
GO_0034115 | Biological process | negative regulation of heterotypic cell-cell adhesion |
GO_2000660 | Biological process | negative regulation of interleukin-1-mediated signaling pathway |
GO_0006955 | Biological process | immune response |
GO_0051384 | Biological process | response to glucocorticoid |
GO_0030073 | Biological process | insulin secretion |
GO_0006629 | Biological process | lipid metabolic process |
GO_0005615 | Cellular component | extracellular space |
GO_0005886 | Cellular component | plasma membrane |
GO_0005813 | Cellular component | centrosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0045352 | Molecular function | interleukin-1 type I receptor antagonist activity |
GO_0045353 | Molecular function | interleukin-1 type II receptor antagonist activity |
GO_0005151 | Molecular function | interleukin-1, type II receptor binding |
GO_0005152 | Molecular function | interleukin-1 receptor antagonist activity |
GO_0005150 | Molecular function | interleukin-1, type I receptor binding |
GO_0005515 | Molecular function | protein binding |
GO_0005125 | Molecular function | cytokine activity |
Gene name | IL1RN |
Protein name | Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra) Interleukin 1 receptor antagonist |
Synonyms | IL1RA IL1F3 |
Description | FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. . |
Accessions | ENST00000354115.6 [P18510-2] ENST00000259206.9 [P18510-3] ENST00000409930.4 [P18510-1] ENST00000696879.1 [P18510-4] A0A8Q3WMN6 ENST00000409052.6 [P18510-4] P18510 ENST00000361779.7 [P18510-4] ENST00000696882.1 ENST00000696881.1 [P18510-4] ENST00000696880.1 [P18510-4] |