IL1RN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0034115Biological processnegative regulation of heterotypic cell-cell adhesion
GO_2000660Biological processnegative regulation of interleukin-1-mediated signaling pathway
GO_0006955Biological processimmune response
GO_0051384Biological processresponse to glucocorticoid
GO_0030073Biological processinsulin secretion
GO_0006629Biological processlipid metabolic process
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045352Molecular functioninterleukin-1 type I receptor antagonist activity
GO_0045353Molecular functioninterleukin-1 type II receptor antagonist activity
GO_0005151Molecular functioninterleukin-1, type II receptor binding
GO_0005152Molecular functioninterleukin-1 receptor antagonist activity
GO_0005150Molecular functioninterleukin-1, type I receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL1RN
Protein nameInterleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra)
Interleukin 1 receptor antagonist
SynonymsIL1RA
IL1F3
DescriptionFUNCTION: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. .

AccessionsENST00000354115.6 [P18510-2]
ENST00000259206.9 [P18510-3]
ENST00000409930.4 [P18510-1]
ENST00000696879.1 [P18510-4]
A0A8Q3WMN6
ENST00000409052.6 [P18510-4]
P18510
ENST00000361779.7 [P18510-4]
ENST00000696882.1
ENST00000696881.1 [P18510-4]
ENST00000696880.1 [P18510-4]