ULK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_1903059Biological processregulation of protein lipidation
GO_0000045Biological processautophagosome assembly
GO_0031175Biological processneuron projection development
GO_0007165Biological processsignal transduction
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0016236Biological processmacroautophagy
GO_0031102Biological processneuron projection regeneration
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0042594Biological processresponse to starvation
GO_0031669Biological processcellular response to nutrient levels
GO_0010508Biological processpositive regulation of autophagy
GO_0048675Biological processaxon extension
GO_0000422Biological processautophagy of mitochondrion
GO_0061709Biological processreticulophagy
GO_0006914Biological processautophagy
GO_0008104Biological processprotein localization
GO_0016241Biological processregulation of macroautophagy
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0048671Biological processnegative regulation of collateral sprouting
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0055037Cellular componentrecycling endosome
GO_0000421Cellular componentautophagosome membrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005829Cellular componentcytosol
GO_1990316Cellular componentAtg1/ULK1 kinase complex
GO_0005776Cellular componentautophagosome
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_1903349Cellular componentomegasome membrane
GO_0030424Cellular componentaxon
GO_0106310Molecular functionprotein serine kinase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0051020Molecular functionGTPase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameULK1
Protein nameSerine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)
SynonymsKIAA0722
DescriptionFUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation . Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes . Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR . Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity . May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences . Plays a role early in neuronal differentiation and is required for granule cell axon formation . Also phosphorylates SESN2 and SQSTM1 to regulate autophagy . Phosphorylates FLCN, promoting autophagy . Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation . Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B . .

AccessionsENST00000321867.6
O75385