GPI | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	21 studies	35% ± 17%	Explore
regulatory T cell	18 studies	35% ± 14%	Explore
non-classical monocyte	17 studies	31% ± 12%	Explore
macrophage	17 studies	26% ± 8%	Explore
CD4-positive, alpha-beta T cell	16 studies	36% ± 21%	Explore
natural killer cell	15 studies	28% ± 10%	Explore
B cell	13 studies	21% ± 5%	Explore
T cell	13 studies	26% ± 8%	Explore
classical monocyte	13 studies	27% ± 9%	Explore
monocyte	12 studies	25% ± 12%	Explore
endothelial cell	12 studies	32% ± 12%	Explore
pericyte	12 studies	21% ± 4%	Explore
gamma-delta T cell	11 studies	31% ± 9%	Explore
conventional dendritic cell	10 studies	30% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	24% ± 8%	Explore
epithelial cell	10 studies	41% ± 18%	Explore
memory B cell	10 studies	23% ± 8%	Explore
myeloid cell	10 studies	28% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	30% ± 13%	Explore
basal cell	9 studies	31% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	29% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	29% ± 12%	Explore
abnormal cell	9 studies	31% ± 21%	Explore
smooth muscle cell	9 studies	24% ± 10%	Explore
mucosal invariant T cell	9 studies	31% ± 5%	Explore
naive B cell	9 studies	19% ± 4%	Explore
fibroblast	9 studies	27% ± 7%	Explore
adipocyte	9 studies	33% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	34% ± 16%	Explore
glutamatergic neuron	8 studies	41% ± 23%	Explore
mature NK T cell	8 studies	34% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 6%	Explore
astrocyte	8 studies	35% ± 19%	Explore
plasmablast	7 studies	38% ± 23%	Explore
amacrine cell	7 studies	48% ± 13%	Explore
retinal ganglion cell	7 studies	80% ± 26%	Explore
dendritic cell	7 studies	34% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	24% ± 6%	Explore
hematopoietic stem cell	6 studies	28% ± 11%	Explore
neuron	6 studies	39% ± 8%	Explore
retinal cone cell	6 studies	35% ± 11%	Explore
oligodendrocyte precursor cell	6 studies	38% ± 13%	Explore
oligodendrocyte	6 studies	37% ± 11%	Explore
hematopoietic precursor cell	5 studies	45% ± 18%	Explore
ciliated cell	5 studies	23% ± 5%	Explore
ionocyte	5 studies	39% ± 13%	Explore
transit amplifying cell	5 studies	23% ± 5%	Explore
interneuron	5 studies	47% ± 27%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 5%	Explore
myofibroblast cell	5 studies	26% ± 11%	Explore
retina horizontal cell	5 studies	71% ± 12%	Explore
retinal rod cell	5 studies	31% ± 9%	Explore
cardiac muscle cell	5 studies	40% ± 8%	Explore
T follicular helper cell	5 studies	24% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	46% ± 16%	Explore
GABAergic neuron	5 studies	46% ± 21%	Explore
plasma cell	4 studies	40% ± 14%	Explore
secretory cell	4 studies	26% ± 7%	Explore
pancreatic A cell	4 studies	43% ± 20%	Explore
retinal bipolar neuron	4 studies	28% ± 8%	Explore
microglial cell	4 studies	24% ± 4%	Explore
erythroblast	4 studies	25% ± 3%	Explore
lymphocyte	4 studies	23% ± 8%	Explore
mesothelial cell	4 studies	20% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	56% ± 17%	Explore
muscle cell	4 studies	31% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	38% ± 20%	Explore
goblet cell	4 studies	18% ± 3%	Explore
alveolar macrophage	4 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 8%	Explore
plasmacytoid dendritic cell	4 studies	22% ± 5%	Explore
respiratory goblet cell	3 studies	25% ± 6%	Explore
type B pancreatic cell	3 studies	50% ± 17%	Explore
glial cell	3 studies	22% ± 5%	Explore
granule cell	3 studies	19% ± 3%	Explore
progenitor cell	3 studies	26% ± 10%	Explore
GABAergic amacrine cell	3 studies	51% ± 24%	Explore
glycinergic amacrine cell	3 studies	40% ± 15%	Explore
common myeloid progenitor	3 studies	40% ± 8%	Explore
immature B cell	3 studies	26% ± 7%	Explore
retinal pigment epithelial cell	3 studies	43% ± 22%	Explore
OFF-bipolar cell	3 studies	60% ± 28%	Explore
ON-bipolar cell	3 studies	57% ± 31%	Explore
rod bipolar cell	3 studies	45% ± 5%	Explore
exhausted T cell	3 studies	43% ± 16%	Explore
intermediate monocyte	3 studies	34% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	47% ± 22%	Explore
enterocyte	3 studies	19% ± 2%	Explore
enteroendocrine cell	3 studies	25% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 8%	Explore
double negative thymocyte	3 studies	36% ± 3%	Explore
connective tissue cell	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	27% ± 4%	Explore
brain	10 studies	37% ± 16%	Explore
eye	8 studies	33% ± 9%	Explore
lung	7 studies	26% ± 8%	Explore
kidney	5 studies	24% ± 8%	Explore
bone marrow	4 studies	24% ± 7%	Explore
lymph node	4 studies	28% ± 14%	Explore
intestine	4 studies	20% ± 4%	Explore
pancreas	3 studies	48% ± 14%	Explore
heart	3 studies	24% ± 5%	Explore
adipose	3 studies	27% ± 9%	Explore
liver	3 studies	23% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	30498.08	258 / 258	100%	153.03	230 / 230
esophagus	100%	18868.62	1445 / 1445	100%	122.93	183 / 183
intestine	100%	16532.01	966 / 966	100%	135.45	527 / 527
kidney	100%	19190.03	89 / 89	100%	147.05	901 / 901
ovary	100%	9978.85	180 / 180	100%	116.85	430 / 430
stomach	100%	10892.11	359 / 359	100%	121.27	286 / 286
uterus	100%	9428.15	170 / 170	100%	135.87	459 / 459
skin	100%	15693.85	1806 / 1809	100%	158.72	472 / 472
bladder	100%	15721.71	21 / 21	100%	129.06	502 / 504
brain	100%	22665.70	2631 / 2642	100%	74.79	705 / 705
breast	100%	14054.55	459 / 459	99%	99.59	1110 / 1118
thymus	100%	12195.57	651 / 653	100%	62.59	602 / 605
prostate	100%	11299.68	244 / 245	99%	86.07	499 / 502
liver	100%	14017.43	225 / 226	99%	88.29	402 / 406
lung	99%	10174.68	573 / 578	99%	137.39	1147 / 1155
pancreas	87%	4848.03	286 / 328	98%	86.86	175 / 178
adipose	100%	17870.67	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	160.63	80 / 80
lymph node	0%	0	0 / 0	100%	109.38	29 / 29
spleen	100%	11031.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	140.63	45 / 45
ureter	0%	0	0 / 0	100%	62.88	1 / 1
muscle	100%	21467.67	802 / 803	0%	0	0 / 0
blood vessel	100%	13121.84	1333 / 1335	0%	0	0 / 0
heart	98%	25363.18	845 / 861	0%	0	0 / 0
peripheral blood	88%	19619.53	819 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033574	Biological process	response to testosterone
GO_0032355	Biological process	response to estradiol
GO_0035994	Biological process	response to muscle stretch
GO_0002639	Biological process	positive regulation of immunoglobulin production
GO_0001701	Biological process	in utero embryonic development
GO_0006096	Biological process	glycolytic process
GO_0007611	Biological process	learning or memory
GO_0007165	Biological process	signal transduction
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0005975	Biological process	carbohydrate metabolic process
GO_0035902	Biological process	response to immobilization stress
GO_0006959	Biological process	humoral immune response
GO_0046686	Biological process	response to cadmium ion
GO_0007599	Biological process	hemostasis
GO_0034101	Biological process	erythrocyte homeostasis
GO_0001707	Biological process	mesoderm formation
GO_0006094	Biological process	gluconeogenesis
GO_0051156	Biological process	glucose 6-phosphate metabolic process
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0032570	Biological process	response to progesterone
GO_0042593	Biological process	glucose homeostasis
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0034774	Cellular component	secretory granule lumen
GO_0060170	Cellular component	ciliary membrane
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0048029	Molecular function	monosaccharide binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0097367	Molecular function	carbohydrate derivative binding
GO_0008083	Molecular function	growth factor activity
GO_0004347	Molecular function	glucose-6-phosphate isomerase activity
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	GPI
Protein name	Glucose-6-phosphate isomerase Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) Glucose-6-phosphate isomerase (EC 5.3.1.9)
Synonyms
Description	FUNCTION: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis . Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility . Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons . It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion . .
Accessions	ENST00000632407.1 ENST00000592144.5 K7ERK8 ENST00000647446.1 A0A0J9YXM3 ENST00000632704.1 ENST00000590375.5 ENST00000634112.1 ENST00000632543.1 A0A0J9YX90 K7EPY4 ENST00000589640.5 A0A2U3TZU2 ENST00000415930.8 ENST00000632809.1 A0A0J9YXH9 P06744 K7EQ48 A0A0J9YYI8 A0A0J9YXP8 ENST00000591204.5 K7EIL4 ENST00000633375.1 ENST00000633941.1 ENST00000356487.11 [P06744-1] K7ELR7 K7EP41 ENST00000631729.1 ENST00000586425.2 ENST00000633130.1 A0A2R8Y6C7 ENST00000642240.1 A0A0J9YYH3 K7ENA0 A0A0G2JLI6 ENST00000631851.1 ENST00000587521.7 ENST00000592277.5 ENST00000589399.6 A0A2R8YF08 ENST00000587384.6 K7ERC6 ENST00000633059.1 ENST00000633181.1 ENST00000588991.7 [P06744-2]

GPI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review