RPS6KB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006412Biological processtranslation
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0031929Biological processTOR signaling
GO_0045948Biological processpositive regulation of translational initiation
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0042277Molecular functionpeptide binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004711Molecular functionribosomal protein S6 kinase activity
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameRPS6KB2
Protein nameRibosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta)
Ribosomal protein S6 kinase B2
Ribosomal protein S6 kinase (EC 2.7.11.1)
SynonymsSTK14B
DescriptionFUNCTION: Phosphorylates specifically ribosomal protein S6 . Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 . .

AccessionsR4GN47
Q9UBS0
ENST00000524934.5
ENST00000556575.5
ENST00000525996.7
G3V2F1
E9PIP7
ENST00000312629.10 [Q9UBS0-1]
E9PQF6
ENST00000420069.3
Q9BRS0
ENST00000528964.5 [Q9UBS0-2]