SNX17 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	23 studies	26% ± 6%	Explore
CD8-positive, alpha-beta T cell	20 studies	24% ± 6%	Explore
B cell	18 studies	26% ± 8%	Explore
non-classical monocyte	18 studies	33% ± 14%	Explore
CD4-positive, alpha-beta T cell	18 studies	22% ± 5%	Explore
macrophage	17 studies	24% ± 7%	Explore
classical monocyte	17 studies	29% ± 11%	Explore
conventional dendritic cell	16 studies	31% ± 16%	Explore
fibroblast	15 studies	28% ± 12%	Explore
regulatory T cell	15 studies	27% ± 6%	Explore
naive B cell	14 studies	22% ± 5%	Explore
memory B cell	13 studies	23% ± 6%	Explore
T cell	12 studies	22% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	27% ± 8%	Explore
monocyte	11 studies	24% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	24% ± 6%	Explore
endothelial cell	11 studies	27% ± 11%	Explore
pericyte	11 studies	24% ± 9%	Explore
gamma-delta T cell	11 studies	27% ± 10%	Explore
plasmacytoid dendritic cell	11 studies	30% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	28% ± 6%	Explore
mature NK T cell	10 studies	27% ± 6%	Explore
connective tissue cell	10 studies	26% ± 9%	Explore
smooth muscle cell	10 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	22% ± 5%	Explore
mucosal invariant T cell	9 studies	21% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	26% ± 9%	Explore
dendritic cell	8 studies	37% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	26% ± 6%	Explore
myofibroblast cell	7 studies	27% ± 5%	Explore
epithelial cell	7 studies	33% ± 15%	Explore
basal cell	6 studies	30% ± 16%	Explore
ciliated cell	6 studies	36% ± 7%	Explore
endothelial cell of lymphatic vessel	6 studies	25% ± 8%	Explore
abnormal cell	6 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	29% ± 4%	Explore
precursor B cell	5 studies	29% ± 10%	Explore
myeloid cell	5 studies	28% ± 9%	Explore
T follicular helper cell	5 studies	23% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	28% ± 6%	Explore
hematopoietic precursor cell	4 studies	35% ± 13%	Explore
plasma cell	4 studies	30% ± 11%	Explore
plasmablast	4 studies	48% ± 18%	Explore
exhausted T cell	4 studies	33% ± 6%	Explore
endothelial cell of artery	4 studies	18% ± 3%	Explore
hematopoietic stem cell	4 studies	22% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	34% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	28% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 8%	Explore
pancreatic A cell	3 studies	35% ± 2%	Explore
type B pancreatic cell	3 studies	32% ± 2%	Explore
mononuclear phagocyte	3 studies	35% ± 16%	Explore
neural crest cell	3 studies	17% ± 1%	Explore
vein endothelial cell	3 studies	17% ± 1%	Explore
retinal ganglion cell	3 studies	51% ± 27%	Explore
common myeloid progenitor	3 studies	29% ± 14%	Explore
capillary endothelial cell	3 studies	23% ± 3%	Explore
immature B cell	3 studies	29% ± 5%	Explore
mesothelial cell	3 studies	37% ± 19%	Explore
pro-B cell	3 studies	29% ± 7%	Explore
germinal center B cell	3 studies	26% ± 4%	Explore
endothelial cell of vascular tree	3 studies	21% ± 1%	Explore
intermediate monocyte	3 studies	38% ± 17%	Explore
enteroendocrine cell	3 studies	28% ± 16%	Explore
goblet cell	3 studies	20% ± 4%	Explore
intestinal crypt stem cell	3 studies	17% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 10%	Explore
T-helper 1 cell	3 studies	21% ± 3%	Explore
mast cell	3 studies	25% ± 6%	Explore
double negative thymocyte	3 studies	35% ± 12%	Explore
neuron	3 studies	28% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	28% ± 8%	Explore
lung	7 studies	30% ± 9%	Explore
lymph node	4 studies	22% ± 4%	Explore
pancreas	3 studies	32% ± 2%	Explore
kidney	3 studies	24% ± 4%	Explore
brain	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6062.34	1445 / 1445	100%	74.71	183 / 183
liver	100%	3934.40	226 / 226	100%	84.76	406 / 406
lung	100%	5943.00	578 / 578	100%	115.54	1155 / 1155
ovary	100%	6187.51	180 / 180	100%	108.21	430 / 430
pancreas	100%	3262.03	328 / 328	100%	101.32	178 / 178
skin	100%	6416.24	1809 / 1809	100%	148.01	472 / 472
thymus	100%	6271.23	653 / 653	100%	128.20	605 / 605
breast	100%	6207.38	459 / 459	100%	117.41	1117 / 1118
brain	100%	4252.23	2637 / 2642	100%	135.18	705 / 705
prostate	100%	6292.63	245 / 245	100%	132.81	501 / 502
uterus	100%	6467.29	170 / 170	100%	108.12	458 / 459
kidney	100%	5270.24	89 / 89	100%	109.20	898 / 901
stomach	100%	4513.16	359 / 359	100%	80.31	285 / 286
intestine	100%	5809.60	966 / 966	99%	91.68	524 / 527
bladder	100%	6349.52	21 / 21	99%	106.97	501 / 504
adrenal gland	100%	7629.65	258 / 258	99%	93.02	228 / 230
adipose	100%	6403.18	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	143.59	80 / 80
lymph node	0%	0	0 / 0	100%	168.81	29 / 29
spleen	100%	8286.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	103.72	45 / 45
ureter	0%	0	0 / 0	100%	55.79	1 / 1
blood vessel	100%	6092.08	1334 / 1335	0%	0	0 / 0
muscle	99%	3024.30	797 / 803	0%	0	0 / 0
heart	99%	3985.49	854 / 861	0%	0	0 / 0
peripheral blood	99%	5656.52	916 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0035904	Biological process	aorta development
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0007165	Biological process	signal transduction
GO_0001822	Biological process	kidney development
GO_0006886	Biological process	intracellular protein transport
GO_0060976	Biological process	coronary vasculature development
GO_0032456	Biological process	endocytic recycling
GO_0003279	Biological process	cardiac septum development
GO_0016197	Biological process	endosomal transport
GO_0030100	Biological process	regulation of endocytosis
GO_0006707	Biological process	cholesterol catabolic process
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0005769	Cellular component	early endosome
GO_0032991	Cellular component	protein-containing complex
GO_0005794	Cellular component	Golgi apparatus
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0010008	Cellular component	endosome membrane
GO_0005768	Cellular component	endosome
GO_0005102	Molecular function	signaling receptor binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0050750	Molecular function	low-density lipoprotein particle receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SNX17
Protein name	Sorting nexin 17 Sorting nexin-17 Sorting nexin 17, isoform CRA_a (cDNA FLJ51047, highly similar to Sorting nexin-17) (cDNA FLJ53821, highly similar to Sorting nexin-17) (cDNA FLJ61770, highly similar to Sorting nexin-17)
Synonyms	KIAA0064 hCG_1784432
Description	FUNCTION: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels . Binds to NPxY sequences in the cytoplasmic tails of target cargos . Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits . Also required for maintenance of normal cell surface levels of APP and LRP1 . Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) . .
Accessions	F8WFA0 Q15036 ENST00000440760.5 F8WAZ0 F8WEG6 ENST00000427123.5 B4DDM3 ENST00000233575.7 [Q15036-1] ENST00000453453.1 ENST00000537606.5 [Q15036-2]

SNX17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review