I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 17% ± 2% | |
| neuron | 4 studies | 27% ± 11% | |
| retinal ganglion cell | 3 studies | 59% ± 25% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 17% ± 2% | |
| neuron | 4 studies | 27% ± 11% | |
| retinal ganglion cell | 3 studies | 59% ± 25% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 26% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 7423.56 | 2642 / 2642 | 100% | 63.47 | 705 / 705 |
| kidney | 100% | 2544.96 | 89 / 89 | 100% | 24.48 | 899 / 901 |
| esophagus | 100% | 2485.31 | 1441 / 1445 | 100% | 18.81 | 183 / 183 |
| thymus | 100% | 2836.38 | 653 / 653 | 100% | 23.93 | 603 / 605 |
| adrenal gland | 100% | 1841.85 | 258 / 258 | 100% | 65.82 | 229 / 230 |
| uterus | 100% | 2379.36 | 170 / 170 | 99% | 24.46 | 456 / 459 |
| stomach | 100% | 1845.71 | 359 / 359 | 99% | 18.30 | 284 / 286 |
| skin | 99% | 1771.39 | 1795 / 1809 | 100% | 26.62 | 472 / 472 |
| intestine | 100% | 2944.25 | 966 / 966 | 99% | 20.95 | 522 / 527 |
| prostate | 100% | 2561.04 | 244 / 245 | 99% | 19.98 | 499 / 502 |
| lung | 100% | 3000.43 | 578 / 578 | 99% | 21.55 | 1143 / 1155 |
| breast | 100% | 2033.11 | 459 / 459 | 99% | 20.49 | 1102 / 1118 |
| bladder | 100% | 2235.57 | 21 / 21 | 98% | 20.65 | 496 / 504 |
| pancreas | 100% | 1353.22 | 327 / 328 | 98% | 30.02 | 175 / 178 |
| ovary | 100% | 1536.51 | 180 / 180 | 95% | 15.84 | 410 / 430 |
| liver | 89% | 933.51 | 201 / 226 | 95% | 12.28 | 384 / 406 |
| eye | 0% | 0 | 0 / 0 | 100% | 27.18 | 80 / 80 |
| spleen | 100% | 3393.75 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 22.95 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.64 | 1 / 1 |
| blood vessel | 100% | 2841.05 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2038.86 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 2002.33 | 857 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 2042.73 | 910 / 929 | 0% | 0 | 0 / 0 |
| muscle | 97% | 1534.30 | 782 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 15.48 | 27 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0050730 | Biological process | regulation of peptidyl-tyrosine phosphorylation |
| GO_0051388 | Biological process | positive regulation of neurotrophin TRK receptor signaling pathway |
| GO_0006470 | Biological process | protein dephosphorylation |
| GO_0031952 | Biological process | regulation of protein autophosphorylation |
| GO_0031334 | Biological process | positive regulation of protein-containing complex assembly |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0070317 | Biological process | negative regulation of G0 to G1 transition |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0000159 | Cellular component | protein phosphatase type 2A complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0072542 | Molecular function | protein phosphatase activator activity |
| GO_0019888 | Molecular function | protein phosphatase regulator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PPP2R5B |
| Protein name | Protein phosphatase 2 regulatory subunit B'beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) |
| Synonyms | |
| Description | FUNCTION: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. . |
| Accessions | Q15173 E9PQN5 E9PNY3 ENST00000532850.1 ENST00000526559.5 ENST00000164133.7 [Q15173-1] |
