TYMP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	43 studies	56% ± 22%	Explore
dendritic cell	29 studies	64% ± 21%	Explore
classical monocyte	28 studies	75% ± 14%	Explore
conventional dendritic cell	28 studies	64% ± 17%	Explore
monocyte	27 studies	62% ± 23%	Explore
non-classical monocyte	26 studies	78% ± 18%	Explore
fibroblast	22 studies	29% ± 13%	Explore
B cell	19 studies	22% ± 6%	Explore
ciliated cell	18 studies	35% ± 14%	Explore
plasmacytoid dendritic cell	16 studies	33% ± 13%	Explore
myeloid cell	16 studies	52% ± 24%	Explore
plasma cell	15 studies	37% ± 15%	Explore
regulatory T cell	15 studies	30% ± 12%	Explore
neutrophil	13 studies	43% ± 18%	Explore
mast cell	11 studies	21% ± 4%	Explore
endothelial cell	11 studies	24% ± 9%	Explore
basal cell	10 studies	25% ± 7%	Explore
epithelial cell	9 studies	29% ± 15%	Explore
T cell	8 studies	25% ± 9%	Explore
alveolar macrophage	8 studies	54% ± 9%	Explore
natural killer cell	8 studies	20% ± 3%	Explore
pericyte	8 studies	26% ± 13%	Explore
CD4-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	8 studies	21% ± 7%	Explore
leukocyte	8 studies	34% ± 13%	Explore
mononuclear phagocyte	8 studies	56% ± 23%	Explore
memory B cell	8 studies	26% ± 8%	Explore
microglial cell	8 studies	33% ± 21%	Explore
type I pneumocyte	7 studies	26% ± 9%	Explore
smooth muscle cell	6 studies	23% ± 8%	Explore
plasmablast	6 studies	38% ± 13%	Explore
naive B cell	6 studies	24% ± 8%	Explore
connective tissue cell	6 studies	33% ± 16%	Explore
capillary endothelial cell	6 studies	26% ± 5%	Explore
intermediate monocyte	6 studies	74% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	21% ± 4%	Explore
club cell	5 studies	20% ± 4%	Explore
respiratory goblet cell	5 studies	32% ± 16%	Explore
secretory cell	5 studies	26% ± 6%	Explore
IgG plasma cell	5 studies	28% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	26% ± 9%	Explore
IgA plasma cell	4 studies	24% ± 6%	Explore
enterocyte	4 studies	26% ± 5%	Explore
adventitial cell	4 studies	20% ± 4%	Explore
vein endothelial cell	4 studies	19% ± 1%	Explore
inflammatory macrophage	4 studies	57% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	31% ± 5%	Explore
endothelial cell of vascular tree	4 studies	19% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 7%	Explore
duct epithelial cell	3 studies	25% ± 10%	Explore
squamous epithelial cell	3 studies	41% ± 22%	Explore
monocyte-derived dendritic cell	3 studies	75% ± 18%	Explore
exhausted T cell	3 studies	24% ± 3%	Explore
hematopoietic precursor cell	3 studies	23% ± 6%	Explore
abnormal cell	3 studies	45% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	17% ± 2%	Explore
common myeloid progenitor	3 studies	24% ± 6%	Explore
innate lymphoid cell	3 studies	41% ± 24%	Explore
endothelial cell of artery	3 studies	20% ± 2%	Explore
tissue-resident macrophage	3 studies	65% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 3%	Explore
T-helper 17 cell	3 studies	23% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	29% ± 10%	Explore
lung	15 studies	31% ± 12%	Explore
intestine	6 studies	22% ± 7%	Explore
breast	4 studies	27% ± 3%	Explore
kidney	3 studies	32% ± 8%	Explore
placenta	3 studies	22% ± 5%	Explore
uterus	3 studies	23% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	8601.79	577 / 578	97%	115.86	1119 / 1155
breast	100%	4084.37	459 / 459	95%	85.11	1066 / 1118
esophagus	92%	2777.13	1334 / 1445	97%	127.97	177 / 183
liver	100%	4044.13	225 / 226	87%	66.12	354 / 406
kidney	91%	3428.25	81 / 89	86%	63.34	777 / 901
skin	89%	1848.14	1618 / 1809	84%	73.04	398 / 472
intestine	88%	2003.80	853 / 966	77%	52.64	408 / 527
thymus	100%	3142.29	652 / 653	62%	39.21	377 / 605
bladder	81%	1931.67	17 / 21	81%	98.32	408 / 504
stomach	70%	1173.49	250 / 359	83%	56.70	236 / 286
uterus	61%	1106.57	103 / 170	89%	179.04	409 / 459
pancreas	45%	717.59	149 / 328	93%	92.03	166 / 178
prostate	95%	2533.95	233 / 245	38%	12.69	193 / 502
adrenal gland	91%	1935.06	236 / 258	13%	6.96	29 / 230
adipose	100%	5098.07	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	204.74	29 / 29
spleen	100%	8367.63	241 / 241	0%	0	0 / 0
peripheral blood	100%	12694.63	928 / 929	0%	0	0 / 0
ovary	23%	284.13	42 / 180	75%	40.36	322 / 430
tonsil	0%	0	0 / 0	98%	361.25	44 / 45
heart	86%	1543.31	738 / 861	0%	0	0 / 0
blood vessel	70%	1641.20	938 / 1335	0%	0	0 / 0
brain	25%	392.75	666 / 2642	32%	14.97	223 / 705
eye	0%	0	0 / 0	40%	19.81	32 / 80
muscle	24%	241.59	191 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0031641	Biological process	regulation of myelination
GO_0001525	Biological process	angiogenesis
GO_0006213	Biological process	pyrimidine nucleoside metabolic process
GO_0051969	Biological process	regulation of transmission of nerve impulse
GO_0006935	Biological process	chemotaxis
GO_0006206	Biological process	pyrimidine nucleobase metabolic process
GO_0030154	Biological process	cell differentiation
GO_0000002	Biological process	mitochondrial genome maintenance
GO_1905333	Biological process	regulation of gastric motility
GO_0046074	Biological process	dTMP catabolic process
GO_0005829	Cellular component	cytosol
GO_0009032	Molecular function	thymidine phosphorylase activity
GO_0004645	Molecular function	1,4-alpha-oligoglucan phosphorylase activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0005515	Molecular function	protein binding
GO_0008083	Molecular function	growth factor activity

IV. Literature review

[source]

Gene name	TYMP
Protein name	Thymidine phosphorylase isoform 2 Thymidine phosphorylase Thymidine phosphorylase (TP) (EC 2.4.2.4) (TdRPase) Thymidine phosphorylase isoform 3 Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)
Synonyms	hCG_1988078 ECGF1
Description	FUNCTION: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. .; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. . FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. .
Accessions	A0A0S2Z3P7 ENST00000652352.1 A0A494C0L3 ENST00000252029.8 [P19971-1] A0A494C1N7 P19971 ENST00000651401.1 ENST00000395681.6 [P19971-2] A0A494C0A4 A0A494C0L6 ENST00000650719.1 A0A494C1L9 C9JGI3 ENST00000395678.7 [P19971-1] E5KRG5 ENST00000395680.6 [P19971-1] A0A494BZZ4 ENST00000487577.5 [P19971-1] ENST00000651490.1 ENST00000652401.1 ENST00000425169.1 A0A0S2Z488 ENST00000651196.1

TYMP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review