Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2495.54 | 245 / 245 | 100% | 16.28 | 502 / 502 |
thymus | 100% | 3847.69 | 653 / 653 | 100% | 17.41 | 604 / 605 |
lung | 100% | 5913.63 | 578 / 578 | 99% | 12.34 | 1147 / 1155 |
breast | 100% | 3753.21 | 459 / 459 | 99% | 12.27 | 1110 / 1118 |
esophagus | 100% | 2476.80 | 1438 / 1445 | 99% | 11.70 | 181 / 183 |
uterus | 100% | 2649.50 | 170 / 170 | 96% | 10.59 | 441 / 459 |
bladder | 95% | 1989.29 | 20 / 21 | 98% | 10.00 | 494 / 504 |
stomach | 97% | 1117.80 | 347 / 359 | 90% | 5.76 | 257 / 286 |
kidney | 100% | 1617.20 | 89 / 89 | 86% | 12.00 | 772 / 901 |
intestine | 97% | 1564.96 | 936 / 966 | 87% | 5.06 | 457 / 527 |
skin | 85% | 2745.96 | 1537 / 1809 | 94% | 8.86 | 444 / 472 |
pancreas | 80% | 679.81 | 261 / 328 | 97% | 9.79 | 173 / 178 |
adrenal gland | 99% | 1161.41 | 255 / 258 | 75% | 4.37 | 173 / 230 |
brain | 67% | 927.72 | 1769 / 2642 | 94% | 4.18 | 662 / 705 |
ovary | 74% | 823.47 | 133 / 180 | 74% | 3.39 | 320 / 430 |
liver | 50% | 340.58 | 113 / 226 | 59% | 2.57 | 240 / 406 |
adipose | 100% | 4090.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 5306.64 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.90 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.69 | 1 / 1 |
heart | 99% | 1615.24 | 851 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 17.75 | 28 / 29 |
eye | 0% | 0 | 0 / 0 | 96% | 11.10 | 77 / 80 |
muscle | 95% | 1115.88 | 759 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 3559.67 | 851 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 83% | 1167.98 | 1109 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010744 | Biological process | positive regulation of macrophage derived foam cell differentiation |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0032056 | Biological process | positive regulation of translation in response to stress |
GO_0060252 | Biological process | positive regulation of glial cell proliferation |
GO_0007165 | Biological process | signal transduction |
GO_0050861 | Biological process | positive regulation of B cell receptor signaling pathway |
GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
GO_1903078 | Biological process | positive regulation of protein localization to plasma membrane |
GO_0035556 | Biological process | intracellular signal transduction |
GO_2000810 | Biological process | regulation of bicellular tight junction assembly |
GO_0030154 | Biological process | cell differentiation |
GO_0034198 | Biological process | cellular response to amino acid starvation |
GO_0070528 | Biological process | protein kinase C signaling |
GO_0034351 | Biological process | negative regulation of glial cell apoptotic process |
GO_0006468 | Biological process | protein phosphorylation |
GO_0045618 | Biological process | positive regulation of keratinocyte differentiation |
GO_0017148 | Biological process | negative regulation of translation |
GO_0071901 | Biological process | negative regulation of protein serine/threonine kinase activity |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005911 | Cellular component | cell-cell junction |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0019899 | Molecular function | enzyme binding |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0045182 | Molecular function | translation regulator activity |
GO_0004699 | Molecular function | diacylglycerol-dependent, calcium-independent serine/threonine kinase activity |
GO_0030291 | Molecular function | protein serine/threonine kinase inhibitor activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0120283 | Molecular function | protein serine/threonine kinase binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004697 | Molecular function | diacylglycerol-dependent serine/threonine kinase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | PRKCH |
Protein name | Protein kinase C eta PRKCH protein PRKCH upstream open reading frame 2 (uORF2) (Protein uPEP2) Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) |
Synonyms | PKCL PRKCL |
Description | FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. . FUNCTION: Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF . Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner . In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ . . FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. . |
Accessions | G3V3E7 G3V4X4 G3V520 ENST00000555082.5 [P24723-2] ENST00000556778.5 ENST00000553265.5 ENST00000555542.5 G3V4G6 G3V4Q9 ENST00000553726.5 ENST00000332981.11 [P24723-1] ENST00000557473.1 G3V5Y6 ENST00000553830.1 B5BU77 ENST00000556164.5 P24723 G3V304 ENST00000553831.5 ENST00000555185.5 G3V5U5 ENST00000557294.5 G3V4H0 ENST00000557585.5 Q9BVQ0 G3V4L3 G3V5F8 G3V4Q6 C0HM02 ENST00000555906.5 |