PRKCH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0032056Biological processpositive regulation of translation in response to stress
GO_0060252Biological processpositive regulation of glial cell proliferation
GO_0007165Biological processsignal transduction
GO_0050861Biological processpositive regulation of B cell receptor signaling pathway
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0035556Biological processintracellular signal transduction
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_0030154Biological processcell differentiation
GO_0034198Biological processcellular response to amino acid starvation
GO_0070528Biological processprotein kinase C signaling
GO_0034351Biological processnegative regulation of glial cell apoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0017148Biological processnegative regulation of translation
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0045182Molecular functiontranslation regulator activity
GO_0004699Molecular functiondiacylglycerol-dependent, calcium-independent serine/threonine kinase activity
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0004672Molecular functionprotein kinase activity
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKCH
Protein nameProtein kinase C eta
PRKCH protein
PRKCH upstream open reading frame 2 (uORF2) (Protein uPEP2)
Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta)
SynonymsPKCL
PRKCL
DescriptionFUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. .

FUNCTION: Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF . Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner . In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ . .

FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. .

AccessionsG3V3E7
G3V4X4
G3V520
ENST00000555082.5 [P24723-2]
ENST00000556778.5
ENST00000553265.5
ENST00000555542.5
G3V4G6
G3V4Q9
ENST00000553726.5
ENST00000332981.11 [P24723-1]
ENST00000557473.1
G3V5Y6
ENST00000553830.1
B5BU77
ENST00000556164.5
P24723
G3V304
ENST00000553831.5
ENST00000555185.5
G3V5U5
ENST00000557294.5
G3V4H0
ENST00000557585.5
Q9BVQ0
G3V4L3
G3V5F8
G3V4Q6
C0HM02
ENST00000555906.5