RNF14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0160127Biological processprotein-RNA covalent cross-linking repair
GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0072344Biological processrescue of stalled ribosome
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0030521Biological processandrogen receptor signaling pathway
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0000151Cellular componentubiquitin ligase complex
GO_0022626Cellular componentcytosolic ribosome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019787Molecular functionubiquitin-like protein transferase activity
GO_0008270Molecular functionzinc ion binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding

IV. Literature review

[source]
Gene nameRNF14
Protein nameRing finger protein 14
E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14)
SynonymsHRIHFB2038
ARA54
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes . Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation . Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation . Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 . Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome . Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) . May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription . .

AccessionsENST00000506004.5
ENST00000347642.7 [Q9UBS8-1]
D6RAS4
E7EP22
ENST00000356143.5 [Q9UBS8-1]
ENST00000511961.5
D6RA38
ENST00000507291.1
ENST00000513019.5
Q9UBS8
ENST00000512565.5
ENST00000394520.7 [Q9UBS8-1]
ENST00000506938.5
D6RDK2
D6RDU6
ENST00000394514.6 [Q9UBS8-2]
D6R988
D6RBU3
ENST00000506822.5
D6RBK4
ENST00000515613.5
ENST00000394519.5 [Q9UBS8-1]
ENST00000507163.5
D6R996