Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 6 studies | 24% ± 8% | |
| myofibroblast cell | 3 studies | 44% ± 9% | |
| epithelial cell | 3 studies | 23% ± 5% | |
| smooth muscle cell | 3 studies | 27% ± 8% | |
| GABAergic neuron | 3 studies | 36% ± 6% | |
| glutamatergic neuron | 3 studies | 32% ± 10% | |
| hepatocyte | 3 studies | 27% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 23% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 8287.29 | 653 / 653 | 95% | 26.09 | 573 / 605 |
| esophagus | 95% | 2515.40 | 1367 / 1445 | 99% | 28.73 | 181 / 183 |
| prostate | 100% | 4136.26 | 244 / 245 | 93% | 18.59 | 466 / 502 |
| stomach | 99% | 2119.04 | 357 / 359 | 92% | 17.32 | 264 / 286 |
| liver | 96% | 2604.88 | 217 / 226 | 95% | 20.29 | 387 / 406 |
| breast | 100% | 4092.60 | 459 / 459 | 91% | 28.71 | 1017 / 1118 |
| lung | 99% | 2495.42 | 574 / 578 | 91% | 17.62 | 1056 / 1155 |
| bladder | 100% | 5627.52 | 21 / 21 | 91% | 18.32 | 457 / 504 |
| intestine | 98% | 3697.80 | 949 / 966 | 90% | 15.73 | 475 / 527 |
| ovary | 100% | 9939.92 | 180 / 180 | 81% | 11.78 | 348 / 430 |
| uterus | 100% | 7053.95 | 170 / 170 | 76% | 14.19 | 349 / 459 |
| pancreas | 75% | 791.94 | 247 / 328 | 97% | 21.14 | 172 / 178 |
| skin | 99% | 5251.16 | 1799 / 1809 | 71% | 10.02 | 335 / 472 |
| kidney | 85% | 1148.34 | 76 / 89 | 68% | 8.05 | 612 / 901 |
| adrenal gland | 100% | 3728.76 | 258 / 258 | 37% | 4.84 | 85 / 230 |
| brain | 50% | 624.60 | 1313 / 2642 | 80% | 7.11 | 565 / 705 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.35 | 1 / 1 |
| adipose | 100% | 2642.99 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 2235.67 | 1319 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 94% | 14.78 | 75 / 80 |
| heart | 89% | 1451.39 | 764 / 861 | 0% | 0 | 0 / 0 |
| muscle | 87% | 2679.81 | 699 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 10.15 | 33 / 45 |
| spleen | 63% | 615.53 | 153 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 38% | 3.05 | 11 / 29 |
| peripheral blood | 2% | 17.35 | 20 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0046326 | Biological process | positive regulation of glucose import |
| GO_0032869 | Biological process | cellular response to insulin stimulus |
| GO_0032000 | Biological process | positive regulation of fatty acid beta-oxidation |
| GO_0048009 | Biological process | insulin-like growth factor receptor signaling pathway |
| GO_0007165 | Biological process | signal transduction |
| GO_0032868 | Biological process | response to insulin |
| GO_0046627 | Biological process | negative regulation of insulin receptor signaling pathway |
| GO_0046676 | Biological process | negative regulation of insulin secretion |
| GO_0045725 | Biological process | positive regulation of glycogen biosynthetic process |
| GO_0008286 | Biological process | insulin receptor signaling pathway |
| GO_0010907 | Biological process | positive regulation of glucose metabolic process |
| GO_0046628 | Biological process | positive regulation of insulin receptor signaling pathway |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0071398 | Biological process | cellular response to fatty acid |
| GO_0005899 | Cellular component | insulin receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005901 | Cellular component | caveola |
| GO_0005634 | Cellular component | nucleus |
| GO_0005080 | Molecular function | protein kinase C binding |
| GO_0005158 | Molecular function | insulin receptor binding |
| GO_0043548 | Molecular function | phosphatidylinositol 3-kinase binding |
| GO_0005159 | Molecular function | insulin-like growth factor receptor binding |
| GO_0005068 | Molecular function | transmembrane receptor protein tyrosine kinase adaptor activity |
| GO_0042169 | Molecular function | SH2 domain binding |
| GO_0035591 | Molecular function | signaling adaptor activity |
| GO_0030159 | Molecular function | signaling receptor complex adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0001784 | Molecular function | phosphotyrosine residue binding |
| Gene name | IRS1 |
| Protein name | Insulin receptor substrate 1 (IRS-1) Insulin receptor substrate 1 |
| Synonyms | |
| Description | FUNCTION: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). . |
| Accessions | ENST00000305123.6 P35568 W0KMC7 W0KRH6 W0KR29 |
