SRGAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0030336Biological processnegative regulation of cell migration
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameSRGAP1
Protein nameSLIT-ROBO Rho GTPase activating protein 1
SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)
Alternative protein SRGAP1
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1, isoform CRA_a (SLIT-ROBO Rho GTPase-activating protein 1)
SynonymshCG_1818050
KIAA1304
ARHGAP13
DescriptionFUNCTION: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. .

AccessionsG5EA48
ENST00000631006.2
L0R5D0
A0A2X0SFI2
A0A8Q3WKV0
Q7Z6B7
ENST00000355086.8 [Q7Z6B7-1]
ENST00000695902.1
ENST00000631006.3 [Q7Z6B7-2]