NDRG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0010038Biological processresponse to metal ion
GO_0007165Biological processsignal transduction
GO_0032287Biological processperipheral nervous system myelin maintenance
GO_0045576Biological processmast cell activation
GO_0071456Biological processcellular response to hypoxia
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043015Molecular functiongamma-tubulin binding
GO_0045296Molecular functioncadherin binding
GO_0031267Molecular functionsmall GTPase binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDRG1
Protein nameProtein NDRG1 (N-myc downstream-regulated gene 1 protein)
N-myc downstream regulated 1
Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42)
SynonymsDRG1
CAP43
RTP
DescriptionFUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. .

AccessionsENST00000519580.6
ENST00000675600.1
ENST00000676064.1
E5RGM5
ENST00000537882.3
A0A7I2ST14
A0A6Q8PFB3
E5RG99
E5RJ98
ENST00000519228.5
ENST00000675568.1
E5RH82
ENST00000674521.1
ENST00000520943.5
A0A6Q8PFG2
ENST00000675983.1
A0A6Q8PGD3
ENST00000523892.5
A0A6Q8PF06
E5RI76
E5RIR1
A0A6Q8PGF1
ENST00000518480.5
A0A6Q8PFP2
E5RGG6
ENST00000323851.13 [Q92597-1]
A0A6Q8PF28
A0A6Q8PF71
ENST00000675357.1
ENST00000521544.5
A0A6Q8PF16
ENST00000517599.5
ENST00000522377.5
ENST00000675068.1
E5RK17
ENST00000520230.5
ENST00000674925.1
ENST00000674902.1
ENST00000522890.5
ENST00000676005.1
ENST00000518066.5
ENST00000674804.1
ENST00000674605.1
ENST00000414097.6 [Q92597-1]
E7ESM1
Q92597
ENST00000676222.1
A0A6Q8PHF2
E5RIM2
ENST00000522738.1
E5RIV1
E5RJY1
ENST00000674839.1
A0A6Q8PFR8
A0A6Q8PGJ1
ENST00000518176.5
ENST00000676375.1
ENST00000522476.5 [Q92597-2]
ENST00000675172.1
A0A6Q8PHI0