INPP4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0043647Biological processinositol phosphate metabolic process
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031965Cellular componentnuclear membrane
GO_0005886Cellular componentplasma membrane
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0017161Molecular functioninositol-1,3,4-trisphosphate 4-phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0016316Molecular functionphosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO_0052828Molecular functioninositol-3,4-bisphosphate 4-phosphatase activity

IV. Literature review

[source]
Gene nameINPP4A
Protein nameInositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)
phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66)
Inositol polyphosphate-4-phosphatase type I A
Synonyms
DescriptionFUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) . Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). .; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. .

AccessionsENST00000409016.8 [Q96PE3-2]
Q96PE3
ENST00000409540.7 [Q96PE3-4]
A0A9L9PY55
ENST00000409463.5
B8ZZB2
ENST00000523221.1 [Q96PE3-1]
ENST00000706935.1
ENST00000409851.8 [Q96PE3-3]