GRK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0009966Biological processregulation of signal transduction
GO_0031623Biological processreceptor internalization
GO_0006468Biological processprotein phosphorylation
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0022400Biological processregulation of opsin-mediated signaling pathway
GO_0097381Cellular componentphotoreceptor disc membrane
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0050254Molecular functionrhodopsin kinase activity
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameGRK4
Protein nameG protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)
G protein-coupled receptor kinase 4
SynonymsGPRK2L
GPRK4
DescriptionFUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. .

AccessionsENST00000398051.8 [P32298-3]
ENST00000345167.10 [P32298-2]
ENST00000503518.2
D6REW5
ENST00000398052.9 [P32298-1]
ENST00000504933.1 [P32298-4]
P32298