Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte precursor cell | 8 studies | 28% ± 12% | |
glutamatergic neuron | 6 studies | 44% ± 23% | |
retinal cone cell | 6 studies | 29% ± 7% | |
GABAergic neuron | 6 studies | 43% ± 21% | |
astrocyte | 6 studies | 31% ± 11% | |
interneuron | 5 studies | 38% ± 22% | |
neuron | 4 studies | 25% ± 9% | |
cardiac muscle cell | 4 studies | 19% ± 2% | |
oligodendrocyte | 4 studies | 21% ± 2% | |
endothelial cell | 3 studies | 32% ± 4% | |
GABAergic interneuron | 3 studies | 20% ± 0% | |
retinal ganglion cell | 3 studies | 25% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 734.83 | 2642 / 2642 | 100% | 8.20 | 705 / 705 |
adrenal gland | 100% | 385.85 | 258 / 258 | 100% | 5.93 | 229 / 230 |
thymus | 100% | 413.43 | 653 / 653 | 100% | 5.67 | 602 / 605 |
breast | 100% | 313.10 | 459 / 459 | 99% | 3.45 | 1110 / 1118 |
prostate | 99% | 261.25 | 243 / 245 | 100% | 3.42 | 502 / 502 |
skin | 100% | 268.12 | 1802 / 1809 | 98% | 4.04 | 463 / 472 |
ovary | 100% | 405.87 | 180 / 180 | 97% | 3.04 | 416 / 430 |
lung | 99% | 259.96 | 572 / 578 | 97% | 2.64 | 1125 / 1155 |
pancreas | 100% | 333.53 | 328 / 328 | 96% | 2.92 | 171 / 178 |
bladder | 100% | 275.43 | 21 / 21 | 96% | 2.58 | 483 / 504 |
uterus | 99% | 304.14 | 169 / 170 | 96% | 3.21 | 442 / 459 |
kidney | 100% | 243.63 | 89 / 89 | 95% | 2.48 | 853 / 901 |
esophagus | 98% | 246.24 | 1418 / 1445 | 96% | 2.97 | 176 / 183 |
stomach | 100% | 268.16 | 358 / 359 | 92% | 2.11 | 264 / 286 |
intestine | 97% | 260.71 | 934 / 966 | 87% | 1.74 | 456 / 527 |
liver | 92% | 130.67 | 208 / 226 | 78% | 1.40 | 315 / 406 |
adipose | 100% | 311.58 | 1204 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 2.44 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.47 | 1 / 1 |
muscle | 100% | 259.10 | 801 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 313.92 | 1329 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 379.38 | 839 / 861 | 0% | 0 | 0 / 0 |
spleen | 95% | 146.66 | 229 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 1.88 | 27 / 29 |
eye | 0% | 0 | 0 / 0 | 91% | 2.57 | 73 / 80 |
peripheral blood | 23% | 50.76 | 216 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0009966 | Biological process | regulation of signal transduction |
GO_0031623 | Biological process | receptor internalization |
GO_0006468 | Biological process | protein phosphorylation |
GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
GO_0022400 | Biological process | regulation of opsin-mediated signaling pathway |
GO_0097381 | Cellular component | photoreceptor disc membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0050254 | Molecular function | rhodopsin kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0004672 | Molecular function | protein kinase activity |
Gene name | GRK4 |
Protein name | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) G protein-coupled receptor kinase 4 |
Synonyms | GPRK2L GPRK4 |
Description | FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. . |
Accessions | ENST00000398051.8 [P32298-3] ENST00000345167.10 [P32298-2] ENST00000503518.2 D6REW5 ENST00000398052.9 [P32298-1] ENST00000504933.1 [P32298-4] P32298 |