PGLYRP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PGLYRP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PGLYRP1 at tissue level.

III. Associated gene sets

GO_0051701Biological processbiological process involved in interaction with host
GO_0016045Biological processdetection of bacterium
GO_0045087Biological processinnate immune response
GO_0032827Biological processnegative regulation of natural killer cell differentiation involved in immune response
GO_0007165Biological processsignal transduction
GO_0031640Biological processkilling of cells of another organism
GO_0050728Biological processnegative regulation of inflammatory response
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0032689Biological processnegative regulation of type II interferon production
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0009253Biological processpeptidoglycan catabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0097013Cellular componentphagocytic vesicle lumen
GO_1904724Cellular componenttertiary granule lumen
GO_0042834Molecular functionpeptidoglycan binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0048018Molecular functionreceptor ligand activity
GO_0016019Molecular functionpeptidoglycan immune receptor activity
GO_0008745Molecular functionN-acetylmuramoyl-L-alanine amidase activity
GO_0008270Molecular functionzinc ion binding
GO_0030544Molecular functionHsp70 protein binding

IV. Literature review

[source]
Gene namePGLYRP1
Protein namePeptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S)
SynonymsTNFSF3L
PGRP
UNQ639/PRO1269
SBBI68
PGLYRP
DescriptionFUNCTION: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity . Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane . In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement . Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system . Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity . Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor . .

AccessionsENST00000008938.5
O75594