PHLPP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0021766Biological processhippocampus development
GO_0006470Biological processprotein dephosphorylation
GO_0042622Cellular componentphotoreceptor outer segment membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0001917Cellular componentphotoreceptor inner segment
GO_0072686Cellular componentmitotic spindle
GO_0005737Cellular componentcytoplasm
GO_0045171Cellular componentintercellular bridge
GO_0005515Molecular functionprotein binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity

IV. Literature review

[source]
Gene namePHLPP2
Protein namePH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
PH domain and leucine rich repeat protein phosphatase 2
SynonymsPHLPPL
KIAA0931
DescriptionFUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis . Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation . Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity . .

AccessionsQ6ZVD8
H3BS75
ENST00000393524.6 [Q6ZVD8-3]
ENST00000567016.1
I3L187
ENST00000564884.5
H3BMS5
ENST00000568004.5
ENST00000568954.5 [Q6ZVD8-1]