Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 8 studies | 41% ± 26% | |
endothelial cell | 5 studies | 27% ± 7% | |
retinal cone cell | 5 studies | 34% ± 8% | |
GABAergic neuron | 5 studies | 40% ± 20% | |
astrocyte | 5 studies | 28% ± 6% | |
retinal pigment epithelial cell | 4 studies | 30% ± 11% | |
retinal rod cell | 4 studies | 37% ± 7% | |
interneuron | 4 studies | 38% ± 22% | |
epithelial cell | 3 studies | 19% ± 2% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 4% | |
oligodendrocyte | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1222.17 | 459 / 459 | 99% | 5.13 | 1103 / 1118 |
brain | 99% | 2083.30 | 2621 / 2642 | 99% | 7.20 | 701 / 705 |
kidney | 100% | 889.80 | 89 / 89 | 97% | 4.15 | 875 / 901 |
intestine | 100% | 2930.66 | 966 / 966 | 97% | 4.31 | 510 / 527 |
thymus | 100% | 2391.51 | 653 / 653 | 96% | 4.58 | 583 / 605 |
prostate | 100% | 1243.01 | 244 / 245 | 96% | 3.00 | 480 / 502 |
adrenal gland | 100% | 1135.64 | 258 / 258 | 93% | 3.06 | 215 / 230 |
lung | 99% | 1298.98 | 575 / 578 | 91% | 2.62 | 1052 / 1155 |
stomach | 90% | 841.47 | 324 / 359 | 96% | 3.90 | 274 / 286 |
pancreas | 90% | 478.71 | 296 / 328 | 96% | 3.01 | 170 / 178 |
bladder | 100% | 1438.14 | 21 / 21 | 86% | 2.63 | 432 / 504 |
esophagus | 88% | 1250.08 | 1270 / 1445 | 98% | 4.14 | 179 / 183 |
skin | 98% | 1146.99 | 1779 / 1809 | 86% | 2.55 | 408 / 472 |
uterus | 99% | 1675.45 | 169 / 170 | 83% | 2.15 | 382 / 459 |
ovary | 100% | 1688.23 | 180 / 180 | 76% | 1.83 | 328 / 430 |
liver | 82% | 422.30 | 185 / 226 | 76% | 1.95 | 310 / 406 |
blood vessel | 100% | 1412.13 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 901.23 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.11 | 1 / 1 |
adipose | 100% | 1406.08 | 1202 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 3.19 | 26 / 29 |
heart | 88% | 611.93 | 758 / 861 | 0% | 0 | 0 / 0 |
muscle | 79% | 429.24 | 638 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 69% | 1.44 | 31 / 45 |
peripheral blood | 30% | 449.43 | 275 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 28% | 0.50 | 22 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0021766 | Biological process | hippocampus development |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0042622 | Cellular component | photoreceptor outer segment membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0001917 | Cellular component | photoreceptor inner segment |
GO_0072686 | Cellular component | mitotic spindle |
GO_0005737 | Cellular component | cytoplasm |
GO_0045171 | Cellular component | intercellular bridge |
GO_0005515 | Molecular function | protein binding |
GO_0017018 | Molecular function | myosin phosphatase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
Gene name | PHLPP2 |
Protein name | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) PH domain and leucine rich repeat protein phosphatase 2 |
Synonyms | PHLPPL KIAA0931 |
Description | FUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis . Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation . Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity . . |
Accessions | Q6ZVD8 H3BS75 ENST00000393524.6 [Q6ZVD8-3] ENST00000567016.1 I3L187 ENST00000564884.5 H3BMS5 ENST00000568004.5 ENST00000568954.5 [Q6ZVD8-1] |