SPX report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPX at tissue level.

III. Associated gene sets

GO_0032099Biological processnegative regulation of appetite
GO_0007165Biological processsignal transduction
GO_1904306Biological processpositive regulation of gastro-intestinal system smooth muscle contraction
GO_0010459Biological processnegative regulation of heart rate
GO_0003084Biological processpositive regulation of systemic arterial blood pressure
GO_0051930Biological processregulation of sensory perception of pain
GO_0044539Biological processlong-chain fatty acid import into cell
GO_0035814Biological processnegative regulation of renal sodium excretion
GO_0005615Cellular componentextracellular space
GO_0031045Cellular componentdense core granule
GO_0005737Cellular componentcytoplasm
GO_0030133Cellular componenttransport vesicle
GO_0005515Molecular functionprotein binding
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene nameSPX
Protein nameSpexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)]
Alternative protein C12orf39
Spexin hormone
SynonymsC12orf39
DescriptionFUNCTION: Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). .; FUNCTION: [Spexin-1]: Acts as a ligand for galanin receptors GALR2 and GALR3 . Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). .; FUNCTION: [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). .

AccessionsENST00000546199.1
A0A3B3ISF3
F5GXE5
ENST00000535033.5
Q9BT56
L8E9B5
ENST00000256969.7