CKLF report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	34% ± 14%	Explore
CD8-positive, alpha-beta T cell	28 studies	36% ± 13%	Explore
macrophage	27 studies	33% ± 13%	Explore
T cell	26 studies	30% ± 13%	Explore
conventional dendritic cell	26 studies	51% ± 16%	Explore
CD4-positive, alpha-beta T cell	24 studies	30% ± 15%	Explore
classical monocyte	22 studies	38% ± 12%	Explore
mast cell	21 studies	46% ± 16%	Explore
regulatory T cell	20 studies	35% ± 13%	Explore
dendritic cell	19 studies	42% ± 22%	Explore
monocyte	18 studies	36% ± 15%	Explore
non-classical monocyte	16 studies	29% ± 12%	Explore
gamma-delta T cell	16 studies	36% ± 15%	Explore
mature NK T cell	15 studies	32% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	30% ± 9%	Explore
mucosal invariant T cell	12 studies	32% ± 10%	Explore
B cell	11 studies	20% ± 8%	Explore
myeloid cell	11 studies	29% ± 13%	Explore
neutrophil	10 studies	34% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	28% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	34% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	27% ± 10%	Explore
endothelial cell	9 studies	29% ± 10%	Explore
leukocyte	8 studies	33% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	28% ± 7%	Explore
innate lymphoid cell	8 studies	37% ± 11%	Explore
plasma cell	7 studies	28% ± 14%	Explore
plasmacytoid dendritic cell	7 studies	25% ± 7%	Explore
microglial cell	7 studies	31% ± 12%	Explore
T follicular helper cell	7 studies	32% ± 9%	Explore
plasmablast	6 studies	43% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	37% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	25% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	25% ± 7%	Explore
alveolar macrophage	5 studies	27% ± 9%	Explore
exhausted T cell	5 studies	44% ± 8%	Explore
mononuclear phagocyte	5 studies	44% ± 12%	Explore
epithelial cell	4 studies	39% ± 8%	Explore
ciliated cell	4 studies	38% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	36% ± 10%	Explore
group 3 innate lymphoid cell	4 studies	49% ± 13%	Explore
T-helper 17 cell	4 studies	55% ± 3%	Explore
T-helper 1 cell	4 studies	45% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 5%	Explore
pancreatic A cell	3 studies	35% ± 6%	Explore
monocyte-derived dendritic cell	3 studies	58% ± 28%	Explore
hematopoietic precursor cell	3 studies	45% ± 20%	Explore
common myeloid progenitor	3 studies	27% ± 10%	Explore
lymphocyte	3 studies	42% ± 13%	Explore
fibroblast	3 studies	26% ± 10%	Explore
intraepithelial lymphocyte	3 studies	60% ± 23%	Explore
erythroblast	3 studies	33% ± 17%	Explore
intermediate monocyte	3 studies	50% ± 16%	Explore
granulocyte	3 studies	47% ± 25%	Explore
endothelial cell of lymphatic vessel	3 studies	23% ± 8%	Explore
CD4-positive helper T cell	3 studies	42% ± 14%	Explore
basal cell	3 studies	29% ± 9%	Explore
double negative thymocyte	3 studies	32% ± 15%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	29% ± 8%	Explore
lung	11 studies	24% ± 8%	Explore
liver	6 studies	32% ± 14%	Explore
intestine	5 studies	25% ± 5%	Explore
kidney	4 studies	24% ± 8%	Explore
brain	4 studies	29% ± 8%	Explore
pancreas	3 studies	27% ± 2%	Explore
bone marrow	3 studies	21% ± 8%	Explore
uterus	3 studies	28% ± 9%	Explore
lymph node	3 studies	26% ± 2%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	99%	257.77	1436 / 1445	38%	0.72	69 / 183
stomach	92%	217.33	331 / 359	20%	0.42	57 / 286
lung	100%	609.93	578 / 578	10%	0.32	120 / 1155
intestine	100%	405.58	966 / 966	9%	0.22	49 / 527
pancreas	91%	166.43	297 / 328	16%	0.29	28 / 178
bladder	100%	357.76	21 / 21	4%	0.19	20 / 504
breast	100%	453.19	459 / 459	3%	0.11	37 / 1118
uterus	100%	377.40	170 / 170	3%	0.07	15 / 459
ovary	100%	350.57	180 / 180	3%	0.04	13 / 430
kidney	99%	307.48	88 / 89	4%	0.10	33 / 901
thymus	100%	327.16	653 / 653	1%	0.02	8 / 605
skin	99%	394.12	1783 / 1809	2%	0.02	8 / 472
adipose	100%	481.33	1204 / 1204	0%	0	0 / 0
adrenal gland	100%	465.37	258 / 258	0%	0	0 / 230
spleen	100%	1013.16	241 / 241	0%	0	0 / 0
prostate	99%	255.53	243 / 245	1%	0.03	3 / 502
brain	98%	211.92	2590 / 2642	2%	0.03	12 / 705
blood vessel	100%	342.75	1329 / 1335	0%	0	0 / 0
peripheral blood	98%	1819.89	907 / 929	0%	0	0 / 0
liver	92%	182.75	207 / 226	0%	0.00	1 / 406
heart	84%	139.04	719 / 861	0%	0	0 / 0
muscle	65%	78.09	519 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.07	2 / 29
tonsil	0%	0	0 / 0	2%	0.02	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1