ITK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046629Biological processgamma-delta T cell activation
GO_0007165Biological processsignal transduction
GO_0050853Biological processB cell receptor signaling pathway
GO_0006968Biological processcellular defense response
GO_0001865Biological processNK T cell differentiation
GO_0050852Biological processT cell receptor signaling pathway
GO_0002250Biological processadaptive immune response
GO_0035556Biological processintracellular signal transduction
GO_0001819Biological processpositive regulation of cytokine production
GO_0006468Biological processprotein phosphorylation
GO_0042110Biological processT cell activation
GO_0005886Cellular componentplasma membrane
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameITK
Protein nameTyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
IL2 inducible T cell kinase
SynonymsLYK
EMT
DescriptionFUNCTION: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation . Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). .

AccessionsA0A8V8TLR2
ENST00000696962.1
ENST00000521769.5
E5RJY4
E5RFR5
ENST00000517779.1
ENST00000422843.8
Q08881