I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 13 studies | 24% ± 8% | |
| smooth muscle cell | 6 studies | 41% ± 16% | |
| myofibroblast cell | 5 studies | 39% ± 16% | |
| adventitial cell | 4 studies | 41% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 13 studies | 24% ± 8% | |
| smooth muscle cell | 6 studies | 41% ± 16% | |
| myofibroblast cell | 5 studies | 39% ± 16% | |
| adventitial cell | 4 studies | 41% ± 9% |
Insufficient scRNA-seq data for expression of CCN5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 79% | 8114.12 | 362 / 459 | 88% | 20.96 | 983 / 1118 |
| lung | 93% | 10290.71 | 539 / 578 | 65% | 4.76 | 749 / 1155 |
| skin | 76% | 9709.70 | 1366 / 1809 | 69% | 23.64 | 328 / 472 |
| ovary | 98% | 9824.94 | 176 / 180 | 23% | 1.56 | 101 / 430 |
| adrenal gland | 55% | 2589.17 | 143 / 258 | 46% | 26.19 | 105 / 230 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.44 | 1 / 1 |
| blood vessel | 100% | 42418.85 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 87% | 18441.94 | 1046 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 63% | 9440.85 | 905 / 1445 | 21% | 2.14 | 39 / 183 |
| uterus | 42% | 4007.69 | 72 / 170 | 33% | 4.62 | 150 / 459 |
| prostate | 31% | 2509.45 | 75 / 245 | 39% | 3.12 | 197 / 502 |
| bladder | 38% | 2252.67 | 8 / 21 | 31% | 2.98 | 158 / 504 |
| heart | 56% | 4631.30 | 482 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 46% | 3.46 | 81 / 178 |
| thymus | 8% | 411.92 | 55 / 653 | 24% | 1.75 | 143 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 2.13 | 13 / 45 |
| kidney | 0% | 0 | 0 / 89 | 24% | 2.90 | 220 / 901 |
| intestine | 12% | 569.80 | 117 / 966 | 9% | 0.52 | 45 / 527 |
| muscle | 18% | 885.82 | 144 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 16% | 3.53 | 13 / 80 |
| liver | 0% | 16.28 | 1 / 226 | 14% | 0.84 | 58 / 406 |
| stomach | 5% | 227.39 | 18 / 359 | 9% | 0.44 | 27 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 3.69 | 4 / 29 |
| brain | 0% | 0 | 0 / 2642 | 3% | 0.09 | 20 / 705 |
| spleen | 2% | 98.78 | 5 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0007155 | Biological process | cell adhesion |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0005615 | Cellular component | extracellular space |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0005634 | Cellular component | nucleus |
| GO_0008201 | Molecular function | heparin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005178 | Molecular function | integrin binding |
| Gene name | CCN5 |
| Protein name | CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2) |
| Synonyms | WISP2 UNQ228/PRO261 CTGFL CT58 |
| Description | FUNCTION: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. |
| Accessions | ENST00000372865.4 [O76076-2] O76076 ENST00000190983.5 [O76076-1] ENST00000372868.6 [O76076-1] |
