PTGES3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	46% ± 18%	Explore
fibroblast	42 studies	48% ± 18%	Explore
macrophage	41 studies	44% ± 16%	Explore
B cell	40 studies	46% ± 12%	Explore
natural killer cell	38 studies	45% ± 14%	Explore
CD8-positive, alpha-beta T cell	37 studies	49% ± 18%	Explore
T cell	36 studies	45% ± 17%	Explore
pericyte	36 studies	48% ± 18%	Explore
CD4-positive, alpha-beta T cell	32 studies	53% ± 17%	Explore
smooth muscle cell	31 studies	47% ± 19%	Explore
conventional dendritic cell	28 studies	49% ± 15%	Explore
regulatory T cell	27 studies	55% ± 15%	Explore
classical monocyte	25 studies	39% ± 14%	Explore
non-classical monocyte	24 studies	59% ± 14%	Explore
epithelial cell	24 studies	54% ± 21%	Explore
dendritic cell	23 studies	44% ± 20%	Explore
endothelial cell of lymphatic vessel	22 studies	48% ± 16%	Explore
basal cell	22 studies	51% ± 19%	Explore
monocyte	21 studies	43% ± 14%	Explore
plasmacytoid dendritic cell	21 studies	48% ± 15%	Explore
mast cell	20 studies	43% ± 17%	Explore
ciliated cell	20 studies	70% ± 21%	Explore
memory B cell	20 studies	51% ± 13%	Explore
gamma-delta T cell	19 studies	48% ± 19%	Explore
mature NK T cell	19 studies	44% ± 13%	Explore
connective tissue cell	19 studies	55% ± 19%	Explore
plasma cell	18 studies	45% ± 17%	Explore
naive B cell	18 studies	39% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	46% ± 14%	Explore
astrocyte	17 studies	33% ± 15%	Explore
mucosal invariant T cell	16 studies	46% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	42% ± 11%	Explore
microglial cell	15 studies	35% ± 16%	Explore
myeloid cell	15 studies	42% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	42% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	49% ± 13%	Explore
capillary endothelial cell	14 studies	42% ± 14%	Explore
myofibroblast cell	14 studies	55% ± 16%	Explore
vein endothelial cell	13 studies	45% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	53% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	53% ± 14%	Explore
oligodendrocyte	12 studies	32% ± 13%	Explore
endothelial cell of artery	12 studies	44% ± 12%	Explore
endothelial cell of vascular tree	12 studies	56% ± 12%	Explore
type I pneumocyte	11 studies	38% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	47% ± 16%	Explore
plasmablast	11 studies	55% ± 22%	Explore
secretory cell	11 studies	50% ± 20%	Explore
goblet cell	11 studies	37% ± 16%	Explore
type II pneumocyte	10 studies	38% ± 17%	Explore
innate lymphoid cell	10 studies	47% ± 13%	Explore
club cell	10 studies	32% ± 16%	Explore
leukocyte	10 studies	53% ± 12%	Explore
progenitor cell	10 studies	56% ± 20%	Explore
abnormal cell	10 studies	58% ± 19%	Explore
neuron	10 studies	51% ± 23%	Explore
mesothelial cell	10 studies	49% ± 26%	Explore
glutamatergic neuron	9 studies	37% ± 20%	Explore
alveolar macrophage	8 studies	39% ± 12%	Explore
T follicular helper cell	8 studies	51% ± 11%	Explore
hematopoietic stem cell	8 studies	55% ± 22%	Explore
erythrocyte	8 studies	46% ± 27%	Explore
GABAergic neuron	8 studies	33% ± 14%	Explore
oligodendrocyte precursor cell	8 studies	33% ± 13%	Explore
respiratory goblet cell	7 studies	27% ± 18%	Explore
platelet	7 studies	25% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	62% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	41% ± 15%	Explore
erythroblast	7 studies	46% ± 29%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	40% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	63% ± 10%	Explore
mononuclear phagocyte	6 studies	47% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	41% ± 8%	Explore
renal alpha-intercalated cell	6 studies	60% ± 7%	Explore
enterocyte	6 studies	35% ± 14%	Explore
IgA plasma cell	6 studies	30% ± 6%	Explore
transit amplifying cell	6 studies	50% ± 22%	Explore
glial cell	6 studies	38% ± 24%	Explore
lymphocyte	6 studies	45% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	61% ± 11%	Explore
interneuron	6 studies	45% ± 20%	Explore
CD4-positive helper T cell	5 studies	44% ± 21%	Explore
hematopoietic precursor cell	5 studies	63% ± 22%	Explore
exhausted T cell	5 studies	54% ± 10%	Explore
ionocyte	5 studies	33% ± 12%	Explore
neutrophil	5 studies	30% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	61% ± 17%	Explore
enteroendocrine cell	5 studies	59% ± 22%	Explore
intestinal crypt stem cell	5 studies	42% ± 17%	Explore
IgG plasma cell	5 studies	25% ± 9%	Explore
retinal ganglion cell	5 studies	65% ± 31%	Explore
retinal rod cell	5 studies	37% ± 14%	Explore
precursor B cell	5 studies	51% ± 20%	Explore
pro-B cell	5 studies	50% ± 17%	Explore
brush cell	5 studies	35% ± 19%	Explore
T-helper 17 cell	5 studies	61% ± 21%	Explore
granulocyte	5 studies	51% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	47% ± 18%	Explore
deuterosomal cell	4 studies	68% ± 15%	Explore
duct epithelial cell	4 studies	26% ± 1%	Explore
pancreatic A cell	4 studies	70% ± 13%	Explore
type B pancreatic cell	4 studies	70% ± 17%	Explore
glomerular endothelial cell	4 studies	42% ± 6%	Explore
OFF-bipolar cell	4 studies	47% ± 25%	Explore
ON-bipolar cell	4 studies	46% ± 25%	Explore
immature B cell	4 studies	52% ± 12%	Explore
amacrine cell	4 studies	55% ± 18%	Explore
retina horizontal cell	4 studies	52% ± 13%	Explore
retinal cone cell	4 studies	48% ± 15%	Explore
retinal pigment epithelial cell	4 studies	46% ± 15%	Explore
adventitial cell	4 studies	43% ± 6%	Explore
mucus secreting cell	4 studies	20% ± 3%	Explore
Mueller cell	4 studies	49% ± 17%	Explore
muscle cell	4 studies	43% ± 19%	Explore
intermediate monocyte	4 studies	54% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	63% ± 9%	Explore
myoepithelial cell	4 studies	52% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	45% ± 14%	Explore
hepatocyte	4 studies	50% ± 30%	Explore
group 3 innate lymphoid cell	4 studies	59% ± 10%	Explore
double negative thymocyte	4 studies	62% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	50% ± 21%	Explore
hillock cell	3 studies	36% ± 12%	Explore
precursor cell	3 studies	73% ± 12%	Explore
pancreatic D cell	3 studies	65% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	51% ± 16%	Explore
podocyte	3 studies	65% ± 12%	Explore
neural crest cell	3 studies	71% ± 11%	Explore
retinal bipolar neuron	3 studies	51% ± 17%	Explore
GABAergic amacrine cell	3 studies	36% ± 13%	Explore
glycinergic amacrine cell	3 studies	34% ± 13%	Explore
renal principal cell	3 studies	61% ± 8%	Explore
thymocyte	3 studies	52% ± 28%	Explore
extravillous trophoblast	3 studies	80% ± 9%	Explore
placental villous trophoblast	3 studies	86% ± 5%	Explore
megakaryocyte	3 studies	42% ± 11%	Explore
neuroendocrine cell	3 studies	52% ± 10%	Explore
Schwann cell	3 studies	56% ± 16%	Explore
serous secreting cell	3 studies	31% ± 9%	Explore
adipocyte	3 studies	20% ± 4%	Explore
tissue-resident macrophage	3 studies	47% ± 15%	Explore
intraepithelial lymphocyte	3 studies	45% ± 14%	Explore
rod bipolar cell	3 studies	44% ± 13%	Explore
acinar cell	3 studies	49% ± 17%	Explore
chondrocyte	3 studies	35% ± 22%	Explore
germinal center B cell	3 studies	46% ± 10%	Explore
pancreatic ductal cell	3 studies	74% ± 10%	Explore
ependymal cell	3 studies	43% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	75% ± 14%	Explore
melanocyte	3 studies	45% ± 4%	Explore
keratinocyte	3 studies	52% ± 5%	Explore
T-helper 1 cell	3 studies	70% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	61% ± 10%	Explore
double-positive, alpha-beta thymocyte	3 studies	74% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	50% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	47% ± 17%	Explore
peripheral blood	18 studies	48% ± 11%	Explore
brain	18 studies	32% ± 15%	Explore
intestine	12 studies	43% ± 20%	Explore
kidney	9 studies	46% ± 13%	Explore
eye	9 studies	43% ± 15%	Explore
bone marrow	6 studies	32% ± 14%	Explore
lymph node	6 studies	53% ± 20%	Explore
liver	6 studies	49% ± 23%	Explore
pancreas	5 studies	57% ± 25%	Explore
heart	5 studies	21% ± 9%	Explore
uterus	5 studies	56% ± 19%	Explore
adipose	5 studies	22% ± 8%	Explore
breast	4 studies	54% ± 5%	Explore
prostate	4 studies	55% ± 21%	Explore
placenta	3 studies	74% ± 5%	Explore
adrenal gland	3 studies	44% ± 17%	Explore
esophagus	3 studies	51% ± 28%	Explore
skin	3 studies	39% ± 16%	Explore
thymus	3 studies	63% ± 26%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	11595.69	1445 / 1445	100%	293.43	183 / 183
ovary	100%	18860.42	180 / 180	100%	282.57	430 / 430
stomach	100%	8499.94	359 / 359	100%	311.93	286 / 286
uterus	100%	15502.41	170 / 170	100%	362.48	458 / 459
lung	100%	13141.31	577 / 578	100%	330.62	1154 / 1155
brain	100%	11063.22	2638 / 2642	100%	289.86	704 / 705
intestine	100%	13085.56	966 / 966	100%	356.75	525 / 527
liver	100%	8508.72	226 / 226	100%	215.04	404 / 406
bladder	100%	14416.76	21 / 21	99%	327.89	501 / 504
thymus	100%	12237.57	653 / 653	99%	271.56	601 / 605
breast	100%	12636.12	459 / 459	99%	366.97	1110 / 1118
prostate	100%	11221.48	245 / 245	99%	278.67	498 / 502
pancreas	99%	6347.84	326 / 328	99%	246.46	177 / 178
kidney	100%	12534.63	89 / 89	99%	225.10	889 / 901
skin	100%	12535.19	1808 / 1809	98%	242.08	463 / 472
adrenal gland	100%	10708.21	258 / 258	97%	221.90	223 / 230
adipose	100%	12422.98	1204 / 1204	0%	0	0 / 0
blood vessel	100%	14428.83	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	291.72	29 / 29
muscle	100%	10774.39	803 / 803	0%	0	0 / 0
spleen	100%	10765.76	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	333.72	45 / 45
ureter	0%	0	0 / 0	100%	124.24	1 / 1
heart	97%	7359.72	837 / 861	0%	0	0 / 0
peripheral blood	96%	10862.49	892 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	159.04	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042327	Biological process	positive regulation of phosphorylation
GO_0019371	Biological process	cyclooxygenase pathway
GO_0005978	Biological process	glycogen biosynthetic process
GO_0007165	Biological process	signal transduction
GO_0060430	Biological process	lung saccule development
GO_0051131	Biological process	chaperone-mediated protein complex assembly
GO_0042921	Biological process	nuclear receptor-mediated glucocorticoid signaling pathway
GO_0006457	Biological process	protein folding
GO_1905323	Biological process	telomerase holoenzyme complex assembly
GO_0050821	Biological process	protein stabilization
GO_0048144	Biological process	fibroblast proliferation
GO_0001516	Biological process	prostaglandin biosynthetic process
GO_0051973	Biological process	positive regulation of telomerase activity
GO_0000723	Biological process	telomere maintenance
GO_0051085	Biological process	chaperone cofactor-dependent protein refolding
GO_0043588	Biological process	skin development
GO_0007004	Biological process	telomere maintenance via telomerase
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005697	Cellular component	telomerase holoenzyme complex
GO_0101031	Cellular component	protein folding chaperone complex
GO_0005829	Cellular component	cytosol
GO_0000781	Cellular component	chromosome, telomeric region
GO_0005634	Cellular component	nucleus
GO_0070182	Molecular function	DNA polymerase binding
GO_0051879	Molecular function	Hsp90 protein binding
GO_0051082	Molecular function	unfolded protein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0050220	Molecular function	prostaglandin-E synthase activity
GO_0003720	Molecular function	telomerase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PTGES3
Protein name	Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) Prostaglandin E synthase 3 (cPGES) (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) Prostaglandin E synthase 3
Synonyms	TEBP hCG_2016483 P23
Description	FUNCTION: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) . Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes . Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway . . FUNCTION: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation. . FUNCTION: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation. .
Accessions	B3KUY2 A0A087WYT3 ENST00000436399.6 [Q15185-2] ENST00000448157.6 [Q15185-4] B4DDC6 ENST00000456859.2 ENST00000614328.4 Q15185 ENST00000414274.7 [Q15185-3] ENST00000262033.11 [Q15185-1]

PTGES3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review