I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 3 studies | 18% ± 0% | |
| hepatocyte | 3 studies | 26% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 3 studies | 18% ± 0% | |
| hepatocyte | 3 studies | 26% ± 10% |
Insufficient scRNA-seq data for expression of ANGPTL8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 7417.08 | 226 / 226 | 94% | 220.07 | 383 / 406 |
| kidney | 93% | 126.08 | 83 / 89 | 24% | 6.24 | 212 / 901 |
| breast | 98% | 804.32 | 448 / 459 | 11% | 0.42 | 125 / 1118 |
| ovary | 94% | 31.69 | 169 / 180 | 6% | 0.08 | 25 / 430 |
| adipose | 99% | 1023.50 | 1194 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 70% | 30.86 | 1018 / 1445 | 27% | 0.48 | 50 / 183 |
| uterus | 94% | 36.51 | 160 / 170 | 2% | 0.05 | 11 / 459 |
| thymus | 89% | 44.65 | 578 / 653 | 3% | 0.04 | 16 / 605 |
| prostate | 88% | 25.42 | 215 / 245 | 2% | 0.03 | 9 / 502 |
| intestine | 78% | 36.11 | 750 / 966 | 8% | 0.25 | 40 / 527 |
| bladder | 81% | 31.38 | 17 / 21 | 3% | 0.09 | 16 / 504 |
| lung | 78% | 20.92 | 451 / 578 | 4% | 0.11 | 45 / 1155 |
| adrenal gland | 73% | 25.07 | 189 / 258 | 5% | 0.83 | 11 / 230 |
| blood vessel | 73% | 76.37 | 969 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 52% | 18.76 | 188 / 359 | 12% | 0.20 | 33 / 286 |
| heart | 54% | 29.53 | 464 / 861 | 0% | 0 | 0 / 0 |
| skin | 48% | 21.36 | 873 / 1809 | 4% | 0.11 | 20 / 472 |
| brain | 43% | 9.45 | 1136 / 2642 | 7% | 0.10 | 49 / 705 |
| pancreas | 26% | 11.50 | 86 / 328 | 7% | 0.23 | 13 / 178 |
| spleen | 30% | 6.32 | 73 / 241 | 0% | 0 | 0 / 0 |
| muscle | 28% | 12.79 | 225 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 10% | 5.78 | 91 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.04 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0044255 | Biological process | cellular lipid metabolic process |
| GO_0007165 | Biological process | signal transduction |
| GO_0070328 | Biological process | triglyceride homeostasis |
| GO_0019216 | Biological process | regulation of lipid metabolic process |
| GO_0044342 | Biological process | type B pancreatic cell proliferation |
| GO_0048469 | Biological process | cell maturation |
| GO_0045444 | Biological process | fat cell differentiation |
| GO_0050746 | Biological process | regulation of lipoprotein metabolic process |
| GO_0010954 | Biological process | positive regulation of protein processing |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ANGPTL8 |
| Protein name | Betatrophin Angiopoietin like 8 (Hepatocellular carcinoma-associated gene TD26, isoform CRA_a) Betatrophin variant 2 Betatrophin variant 1 Angiopoietin like 8 Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein) |
| Synonyms | LOC55908 hCG_29959 RIFL UNQ599/PRO1185 C19orf80 |
| Description | FUNCTION: Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels . May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). . |
| Accessions | Q6UXH0 K7EJY6 W5VK78 W5VKF7 K7EIY2 ENST00000587543.1 ENST00000252453.12 W5VKV0 ENST00000591200.5 |
