I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 22% ± 6% | |
| GABAergic neuron | 3 studies | 28% ± 10% | |
| glutamatergic neuron | 3 studies | 41% ± 8% | |
| astrocyte | 3 studies | 22% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 22% ± 6% | |
| GABAergic neuron | 3 studies | 28% ± 10% | |
| glutamatergic neuron | 3 studies | 41% ± 8% | |
| astrocyte | 3 studies | 22% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 27% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1520.38 | 1445 / 1445 | 100% | 22.82 | 183 / 183 |
| brain | 100% | 1431.10 | 2637 / 2642 | 100% | 29.55 | 705 / 705 |
| lung | 99% | 996.40 | 575 / 578 | 100% | 19.69 | 1153 / 1155 |
| prostate | 100% | 1077.80 | 244 / 245 | 100% | 22.89 | 500 / 502 |
| liver | 100% | 2072.54 | 226 / 226 | 99% | 19.58 | 402 / 406 |
| thymus | 100% | 2324.19 | 653 / 653 | 99% | 18.81 | 599 / 605 |
| kidney | 100% | 1025.66 | 89 / 89 | 99% | 16.89 | 890 / 901 |
| stomach | 100% | 1026.61 | 358 / 359 | 99% | 22.11 | 283 / 286 |
| uterus | 100% | 1201.88 | 170 / 170 | 98% | 16.94 | 450 / 459 |
| breast | 100% | 1010.46 | 459 / 459 | 98% | 14.75 | 1096 / 1118 |
| bladder | 100% | 1023.62 | 21 / 21 | 98% | 17.41 | 494 / 504 |
| intestine | 100% | 1627.62 | 966 / 966 | 98% | 20.74 | 516 / 527 |
| adrenal gland | 100% | 1122.03 | 258 / 258 | 98% | 18.98 | 225 / 230 |
| ovary | 100% | 1212.82 | 180 / 180 | 97% | 11.23 | 419 / 430 |
| pancreas | 98% | 557.38 | 320 / 328 | 98% | 17.50 | 175 / 178 |
| skin | 97% | 783.22 | 1759 / 1809 | 97% | 24.07 | 458 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 18.53 | 29 / 29 |
| spleen | 100% | 1057.07 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.97 | 1 / 1 |
| blood vessel | 100% | 1129.40 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1107.44 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 99% | 716.74 | 795 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 15.17 | 44 / 45 |
| heart | 97% | 1215.76 | 835 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 13.55 | 60 / 80 |
| peripheral blood | 62% | 820.08 | 580 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0006020 | Biological process | inositol metabolic process |
| GO_0006796 | Biological process | phosphate-containing compound metabolic process |
| GO_0006021 | Biological process | inositol biosynthetic process |
| GO_0046854 | Biological process | phosphatidylinositol phosphate biosynthetic process |
| GO_0006661 | Biological process | phosphatidylinositol biosynthetic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030145 | Molecular function | manganese ion binding |
| GO_0052834 | Molecular function | inositol monophosphate phosphatase activity |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0052832 | Molecular function | inositol monophosphate 3-phosphatase activity |
| GO_0052833 | Molecular function | inositol monophosphate 4-phosphatase activity |
| GO_0008934 | Molecular function | inositol monophosphate 1-phosphatase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0031403 | Molecular function | lithium ion binding |
| Gene name | IMPA1 |
| Protein name | Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) inositol-phosphate phosphatase (EC 3.1.3.25) (Lithium-sensitive myo-inositol monophosphatase A1) Inositol-1-monophosphatase (EC 3.1.3.25) Lithium-sensitive myo-inositol monophosphatase A1 |
| Synonyms | IMPA |
| Description | FUNCTION: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. . |
| Accessions | ENST00000311489.8 [P29218-2] E5RHE9 ENST00000256108.10 [P29218-1] ENST00000519816.1 ENST00000519964.5 ENST00000523942.5 ENST00000518202.5 E5RIF4 E5RIP7 P29218 H0YBL1 ENST00000449740.6 [P29218-3] ENST00000518188.5 E5RG94 E5RG13 ENST00000521360.5 E5RI82 ENST00000522997.5 ENST00000521979.5 E5RGY4 |
