DOK1 | OmnibusX

Name	Number of supported studies	Average coverage
classical monocyte	4 studies	23% ± 7%	Explore
conventional dendritic cell	3 studies	25% ± 11%	Explore
non-classical monocyte	3 studies	18% ± 4%	Explore
macrophage	3 studies	19% ± 3%	Explore
dendritic cell	3 studies	27% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of DOK1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	594.47	180 / 180	100%	15.05	430 / 430
thymus	100%	724.07	652 / 653	100%	18.75	604 / 605
stomach	100%	731.35	358 / 359	100%	15.59	285 / 286
intestine	100%	874.26	966 / 966	99%	18.96	522 / 527
lung	100%	1105.57	578 / 578	99%	14.69	1143 / 1155
breast	100%	834.92	459 / 459	97%	21.23	1088 / 1118
uterus	99%	772.22	169 / 170	96%	14.44	439 / 459
bladder	100%	700.33	21 / 21	95%	15.86	478 / 504
pancreas	94%	379.05	307 / 328	99%	20.87	177 / 178
prostate	99%	582.60	242 / 245	93%	6.83	465 / 502
adrenal gland	99%	679.88	256 / 258	92%	12.35	211 / 230
kidney	97%	451.08	86 / 89	93%	13.80	842 / 901
brain	85%	313.19	2249 / 2642	100%	21.23	705 / 705
esophagus	87%	516.62	1261 / 1445	89%	7.79	163 / 183
skin	76%	743.54	1377 / 1809	99%	17.47	466 / 472
adipose	100%	1231.64	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	58.16	29 / 29
peripheral blood	100%	2734.16	929 / 929	0%	0	0 / 0
spleen	100%	2210.79	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.74	1 / 1
blood vessel	100%	745.65	1329 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	98%	7.30	78 / 80
tonsil	0%	0	0 / 0	96%	11.16	43 / 45
heart	80%	251.72	686 / 861	0%	0	0 / 0
liver	23%	63.45	53 / 226	50%	4.06	205 / 406
muscle	8%	16.24	62 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007165	Biological process	signal transduction
GO_0038145	Biological process	macrophage colony-stimulating factor signaling pathway
GO_0007265	Biological process	Ras protein signal transduction
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005829	Cellular component	cytosol
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

Gene name	DOK1
Protein name	DOK1 protein (cDNA FLJ45184 fis, highly similar to Docking protein 1 (Downstream of tyrosine kinase 1)) (cDNA FLJ45754 fis, clone LYMPB2002806, highly similar to Docking protein 1 (Downstream of tyrosine kinase 1)) (cDNA FLJ60879, highly similar to Docking protein 1 (Downstream of tyrosinekinase 1)) Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) DOK1 protein Docking protein 1
Synonyms
Description	FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. .
Accessions	ENST00000409429.5 [Q99704-3] H7C093 ENST00000429631.1 Q2TA81 ENST00000233668.10 [Q99704-1] Q14CB2 Q99704 ENST00000340004.6 [Q99704-2]

DOK1 report