BMP8A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BMP8A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BMP8A at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0097009Biological processenergy homeostasis
GO_0002024Biological processdiet induced thermogenesis
GO_0001503Biological processossification
GO_0030154Biological processcell differentiation
GO_0051216Biological processcartilage development
GO_0046676Biological processnegative regulation of insulin secretion
GO_0005615Cellular componentextracellular space
GO_0005125Molecular functioncytokine activity
GO_0008083Molecular functiongrowth factor activity

IV. Literature review

[source]
Gene nameBMP8A
Protein nameBone morphogenetic protein 8a
BMP8A protein
Bone morphogenetic protein 8A (BMP-8A)
Synonyms
DescriptionFUNCTION: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. .; FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance . Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 . Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway . .

AccessionsQ7Z5Y6
ENST00000331593.6
A2RRG5
Q4G0H3