AKAP8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071380Biological processcellular response to prostaglandin E stimulus
GO_0000278Biological processmitotic cell cycle
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0007076Biological processmitotic chromosome condensation
GO_0015031Biological processprotein transport
GO_0044839Biological processcell cycle G2/M phase transition
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0001939Cellular componentfemale pronucleus
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0005737Cellular componentcytoplasm
GO_0000793Cellular componentcondensed chromosome
GO_0005634Cellular componentnucleus
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0051059Molecular functionNF-kappaB binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameAKAP8
Protein nameA-kinase anchoring protein 8
A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)
AKAP8 protein
SynonymsAKAP95
DescriptionFUNCTION: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) . Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring . May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L . Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation . May be involved in regulation of DNA replication by acting as scaffold for MCM2 . Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation . May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells . May act as a carrier protein of GJA1 for its transport to the nucleus . May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions . Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). .

AccessionsENST00000680245.1
O43823
ENST00000681812.1
A0A7P0TBC8
ENST00000598597.7
Q8NE02
ENST00000269701.7
ENST00000599883.2
ENST00000680461.1
M0QX51
A0A7P0TAA4
A0A7P0T893