SPP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000866Biological processpositive regulation of estradiol secretion
GO_0036005Biological processresponse to macrophage colony-stimulating factor
GO_0046697Biological processdecidualization
GO_0001649Biological processosteoblast differentiation
GO_0007165Biological processsignal transduction
GO_0007155Biological processcell adhesion
GO_0071394Biological processcellular response to testosterone stimulus
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0031214Biological processbiomineral tissue development
GO_0048545Biological processresponse to steroid hormone
GO_0006710Biological processandrogen catabolic process
GO_0045780Biological processpositive regulation of bone resorption
GO_0033280Biological processresponse to vitamin D
GO_0007566Biological processembryo implantation
GO_0048685Biological processnegative regulation of collateral sprouting of intact axon in response to injury
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0042995Cellular componentcell projection
GO_0005178Molecular functionintegrin binding
GO_0005125Molecular functioncytokine activity
GO_0036094Molecular functionsmall molecule binding
GO_0050840Molecular functionextracellular matrix binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPP1
Protein nameSecreted phosphoprotein 1 variant 6 (cDNA FLJ54682, highly similar to Osteopontin)
Osteopontin (Secreted phosphoprotein 1)
Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)
Secreted phosphoprotein 1
SynonymsOPN
BNSP
PSEC0156
opn
DescriptionFUNCTION: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. .; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. .

AccessionsQ3LGB0
ENST00000360804.4 [P10451-3]
ENST00000237623.11 [P10451-5]
ENST00000614857.5 [P10451-1]
P10451
ENST00000682655.1
A0A804HLB3
ENST00000395080.8 [P10451-1]
ENST00000508233.6
B7Z351