PRKAB1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRKAB1 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0031669Biological processcellular response to nutrient levels
GO_0006633Biological processfatty acid biosynthetic process
GO_0006468Biological processprotein phosphorylation
GO_0035878Biological processnail development
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0031588Cellular componentnucleotide-activated protein kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene namePRKAB1
Protein name5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)
Protein kinase AMP-activated non-catalytic subunit beta 1
SynonymsAMPK
DescriptionFUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

AccessionsF5H610
ENST00000545223.1
F5H2X8
Q9Y478
ENST00000630317.1
ENST00000540121.5
ENST00000541640.5
ENST00000537400.1
ENST00000229328.10
F5H4Y8