Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 8 studies | 26% ± 10% | |
| classical monocyte | 7 studies | 21% ± 7% | |
| epithelial cell | 6 studies | 29% ± 15% | |
| endothelial cell | 5 studies | 23% ± 5% | |
| non-classical monocyte | 3 studies | 25% ± 5% | |
| abnormal cell | 3 studies | 22% ± 5% | |
| type I pneumocyte | 3 studies | 18% ± 2% | |
| basal cell | 3 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 5414.23 | 1445 / 1445 | 100% | 38.84 | 183 / 183 |
| ovary | 100% | 5285.57 | 180 / 180 | 100% | 32.95 | 430 / 430 |
| stomach | 100% | 4404.97 | 359 / 359 | 100% | 26.96 | 286 / 286 |
| lung | 100% | 5798.16 | 578 / 578 | 100% | 25.81 | 1154 / 1155 |
| skin | 100% | 6364.76 | 1809 / 1809 | 100% | 33.07 | 470 / 472 |
| intestine | 100% | 5205.63 | 966 / 966 | 99% | 25.79 | 524 / 527 |
| breast | 100% | 5403.19 | 459 / 459 | 99% | 21.72 | 1109 / 1118 |
| prostate | 100% | 5768.82 | 245 / 245 | 99% | 20.77 | 497 / 502 |
| bladder | 100% | 5503.71 | 21 / 21 | 99% | 27.40 | 498 / 504 |
| brain | 99% | 4122.99 | 2626 / 2642 | 99% | 27.18 | 700 / 705 |
| thymus | 100% | 5486.02 | 653 / 653 | 99% | 24.39 | 597 / 605 |
| pancreas | 100% | 2997.71 | 328 / 328 | 98% | 20.92 | 175 / 178 |
| kidney | 100% | 5023.27 | 89 / 89 | 98% | 18.90 | 884 / 901 |
| uterus | 100% | 5495.77 | 170 / 170 | 98% | 25.28 | 450 / 459 |
| adrenal gland | 100% | 5538.93 | 258 / 258 | 97% | 18.74 | 224 / 230 |
| liver | 100% | 2482.90 | 226 / 226 | 92% | 14.87 | 375 / 406 |
| adipose | 100% | 5289.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 33.20 | 80 / 80 |
| spleen | 100% | 6165.43 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 22.45 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.22 | 1 / 1 |
| blood vessel | 100% | 5629.70 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 4304.95 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 2978.00 | 849 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 4171.64 | 914 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 16.21 | 27 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0010642 | Biological process | negative regulation of platelet-derived growth factor receptor signaling pathway |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0031623 | Biological process | receptor internalization |
| GO_0042176 | Biological process | regulation of protein catabolic process |
| GO_0036258 | Biological process | multivesicular body assembly |
| GO_0046426 | Biological process | negative regulation of receptor signaling pathway via JAK-STAT |
| GO_0006622 | Biological process | protein targeting to lysosome |
| GO_0007165 | Biological process | signal transduction |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0010324 | Biological process | membrane invagination |
| GO_0016236 | Biological process | macroautophagy |
| GO_0030948 | Biological process | negative regulation of vascular endothelial growth factor receptor signaling pathway |
| GO_1903543 | Biological process | positive regulation of exosomal secretion |
| GO_0032456 | Biological process | endocytic recycling |
| GO_0090148 | Biological process | membrane fission |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0016197 | Biological process | endosomal transport |
| GO_0043405 | Biological process | regulation of MAP kinase activity |
| GO_0072657 | Biological process | protein localization to membrane |
| GO_0043328 | Biological process | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO_0005769 | Cellular component | early endosome |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0097013 | Cellular component | phagocytic vesicle lumen |
| GO_0005829 | Cellular component | cytosol |
| GO_0033565 | Cellular component | ESCRT-0 complex |
| GO_0005768 | Cellular component | endosome |
| GO_0032585 | Cellular component | multivesicular body membrane |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0035091 | Molecular function | phosphatidylinositol binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0043130 | Molecular function | ubiquitin binding |
| GO_0044389 | Molecular function | ubiquitin-like protein ligase binding |
| Gene name | HGS |
| Protein name | Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) |
| Synonyms | hCG_1987560 HRS |
| Description | FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. . |
| Accessions | A0A7I2V4X6 ENST00000573320.2 I3L1F1 A0A7I2V3A5 A0A7I2V5D6 ENST00000678055.1 ENST00000677818.1 A0A7I2V5A2 ENST00000678176.1 ENST00000678907.1 A0A7I2V5N3 A0A7I2YQY0 ENST00000676462.1 A0A7I2YQM9 A0A7I2V3F9 ENST00000570652.2 A0A7I2V4J7 A0A0S2Z4R4 A0A7I2V558 I3L1E3 A0A7I2V2R9 ENST00000678105.1 ENST00000679036.1 ENST00000676879.1 ENST00000677663.1 A0A7I2V3I8 A0A7I2V2D8 ENST00000678478.1 A0A7I2V468 ENST00000678680.1 A0A7I2V569 ENST00000677012.1 ENST00000677484.1 ENST00000571518.6 ENST00000676963.1 ENST00000677209.1 ENST00000678846.1 A0A7I2V5X2 A0A7I2V6E0 A0A7I2V5E5 ENST00000677225.1 A0A7I2V5A3 A0A7I2V3C3 ENST00000677044.1 A0A7I2V637 ENST00000676665.1 ENST00000677511.1 A0A7I2V3E9 A0A7I2YQD1 A0A7I2V3L0 A0A7I2YQM4 ENST00000678866.1 A0A7I2V3Q7 ENST00000677463.1 ENST00000571237.1 ENST00000676546.1 [O14964-1] ENST00000679170.1 A0A7I2V5V1 ENST00000678748.1 A0A7I2V307 A0A7I2V611 A0A7I2V310 I3L165 ENST00000679340.1 A0A7I2V5W6 A0A7I2V5E7 A0A7I2V4Z5 A0A7I2YQU5 ENST00000329138.9 [O14964-1] ENST00000679336.1 A0A7I2V319 ENST00000676721.1 A0A7I2V5L9 A0A7I2V628 ENST00000575078.6 ENST00000679275.1 A0A7I2V2K1 ENST00000678981.1 I3L326 I3L1P5 ENST00000678607.1 ENST00000678428.1 ENST00000678406.1 A0A7I2V331 ENST00000677243.1 A0A7I2YQP0 ENST00000678893.1 I3L2H4 ENST00000577012.1 O14964 ENST00000678096.1 A0A7I2V2K2 ENST00000679168.1 ENST00000678196.1 ENST00000677728.1 A0A7I2V2M1 ENST00000678142.1 ENST00000677466.1 ENST00000676898.1 A0A7I2V674 A0A7I2V5B7 ENST00000678550.1 ENST00000676729.1 A0A7I2V605 ENST00000676704.1 A0A7I2V3Z1 ENST00000677872.1 ENST00000678926.1 A0A7I2YQH7 ENST00000572392.2 A0A7I2V3J3 ENST00000679146.1 A0A7I2V2W5 ENST00000679191.1 A0A7I2V363 ENST00000677132.1 ENST00000677109.1 A0A7I2YQS8 I3L346 A0A7I2V616 A0A7I2V3N6 ENST00000677706.1 A0A7I2V5C4 A0A7I2V2M4 ENST00000678667.1 ENST00000678565.1 ENST00000678896.1 ENST00000677161.1 ENST00000677188.1 A0A7I2V4M9 ENST00000676478.1 A0A0S2Z4Q4 ENST00000677390.1 |
