RAP2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070527Biological processplatelet aggregation
GO_0007165Biological processsignal transduction
GO_0061097Biological processregulation of protein tyrosine kinase activity
GO_0030168Biological processplatelet activation
GO_0030033Biological processmicrovillus assembly
GO_0032486Biological processRap protein signal transduction
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_0031954Biological processpositive regulation of protein autophosphorylation
GO_0030336Biological processnegative regulation of cell migration
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0044291Cellular componentcell-cell contact zone
GO_0005829Cellular componentcytosol
GO_0070821Cellular componenttertiary granule membrane
GO_0005923Cellular componentbicellular tight junction
GO_0019003Molecular functionGDP binding
GO_0019904Molecular functionprotein domain specific binding
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAP2B
Protein nameRas-related protein Rap-2b (EC 3.6.5.2)
Synonyms
DescriptionFUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. .

AccessionsENST00000323534.5
P61225