PNOC | OmnibusX

Name	Number of supported studies	Average coverage
B cell	13 studies	22% ± 5%	Explore
memory B cell	10 studies	21% ± 4%	Explore
naive B cell	10 studies	18% ± 3%	Explore
plasma cell	7 studies	33% ± 10%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 4%	Explore
GABAergic neuron	3 studies	24% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PNOC at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	78%	105.74	2059 / 2642	52%	4.26	369 / 705
ovary	25%	13.31	45 / 180	95%	75.37	409 / 430
lymph node	0%	0	0 / 0	100%	21.84	29 / 29
spleen	100%	451.67	241 / 241	0%	0	0 / 0
stomach	69%	35.73	247 / 359	31%	0.81	88 / 286
peripheral blood	91%	346.28	850 / 929	0%	0	0 / 0
lung	32%	10.58	186 / 578	52%	2.22	601 / 1155
intestine	57%	66.03	553 / 966	23%	0.64	119 / 527
tonsil	0%	0	0 / 0	56%	2.03	25 / 45
pancreas	0%	0.10	1 / 328	47%	1.61	84 / 178
kidney	26%	15.25	23 / 89	16%	0.65	147 / 901
bladder	19%	5.33	4 / 21	23%	1.11	115 / 504
breast	17%	5.93	76 / 459	22%	0.60	251 / 1118
thymus	15%	14.62	96 / 653	20%	1.00	122 / 605
esophagus	17%	5.02	242 / 1445	17%	0.39	32 / 183
uterus	5%	1.90	9 / 170	29%	3.14	131 / 459
skin	0%	0.14	9 / 1809	31%	1.16	145 / 472
prostate	10%	3.92	25 / 245	3%	0.09	17 / 502
adrenal gland	8%	2.19	20 / 258	2%	0.04	5 / 230
liver	3%	0.60	6 / 226	5%	0.16	20 / 406
adipose	5%	1.73	55 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.10	3 / 80
blood vessel	4%	7.60	50 / 1335	0%	0	0 / 0
heart	1%	0.26	11 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0019233	Biological process	sensory perception of pain
GO_0007165	Biological process	signal transduction
GO_0007218	Biological process	neuropeptide signaling pathway
GO_0007600	Biological process	sensory perception
GO_0007270	Biological process	neuron-neuron synaptic transmission
GO_0007268	Biological process	chemical synaptic transmission
GO_0007565	Biological process	female pregnancy
GO_0097060	Cellular component	synaptic membrane
GO_0043679	Cellular component	axon terminus
GO_0005576	Cellular component	extracellular region
GO_0043025	Cellular component	neuronal cell body
GO_0005886	Cellular component	plasma membrane
GO_0030425	Cellular component	dendrite
GO_0031628	Molecular function	opioid receptor binding
GO_0001515	Molecular function	opioid peptide activity
GO_0005184	Molecular function	neuropeptide hormone activity

Gene name	PNOC
Protein name	Prepronociceptin [Cleaved into: Nocistatin; Nociceptin (Orphanin FQ) (PPNOC); Orphanin FQ2] Prepronociceptin
Synonyms	OFQ
Description	FUNCTION: [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. .; FUNCTION: [Nocistatin]: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. .; FUNCTION: [Orphanin FQ2]: Has potent analgesic activity. .
Accessions	ENST00000301908.8 [Q13519-1] ENST00000522209.1 [Q13519-2] ENST00000518479.5 E7EVP0 Q9BYY3 Q13519

PNOC report