PILRA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0042288Molecular functionMHC class I protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePILRA
Protein namePaired immunoglobin like type 2 receptor alpha
Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha)
Synonyms
DescriptionFUNCTION: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. .; FUNCTION: (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1. .

AccessionsENST00000394000.6 [Q9UKJ1-4]
ENST00000453419.5
C9JGG1
C9JJ79
ENST00000350573.2 [Q9UKJ1-3]
Q9UKJ1
ENST00000198536.7 [Q9UKJ1-1]
ENST00000432297.6