CHL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0008344Biological processadult locomotory behavior
GO_0050890Biological processcognition
GO_0035640Biological processexploration behavior
GO_0001764Biological processneuron migration
GO_0007155Biological processcell adhesion
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0007411Biological processaxon guidance
GO_0070062Cellular componentextracellular exosome
GO_0045177Cellular componentapical part of cell
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030425Cellular componentdendrite
GO_0002020Molecular functionprotease binding

IV. Literature review

[source]
Gene nameCHL1
Protein nameCell adhesion molecule L1 like
Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]
SynonymsCALL
DescriptionFUNCTION: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). .

AccessionsENST00000397491.6 [O00533-1]
F8WEP4
O00533
ENST00000256509.7 [O00533-2]
H7C0J0
A0A087X0M8
ENST00000435603.5
C9JEY3
C9J905
ENST00000445697.1
C9JH37
ENST00000620033.4
ENST00000427688.5
ENST00000421198.5
ENST00000449294.6
ENST00000453040.5
C9JW79