Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 45 studies | 44% ± 22% | |
fibroblast | 43 studies | 36% ± 15% | |
endothelial cell of lymphatic vessel | 22 studies | 44% ± 17% | |
smooth muscle cell | 22 studies | 29% ± 10% | |
pericyte | 20 studies | 31% ± 22% | |
endothelial cell of artery | 16 studies | 48% ± 16% | |
capillary endothelial cell | 15 studies | 34% ± 19% | |
astrocyte | 13 studies | 42% ± 19% | |
myofibroblast cell | 13 studies | 31% ± 9% | |
connective tissue cell | 12 studies | 37% ± 18% | |
oligodendrocyte | 12 studies | 40% ± 13% | |
endothelial cell of vascular tree | 11 studies | 39% ± 25% | |
mast cell | 10 studies | 28% ± 17% | |
glutamatergic neuron | 9 studies | 44% ± 26% | |
vein endothelial cell | 9 studies | 28% ± 11% | |
adipocyte | 9 studies | 46% ± 12% | |
oligodendrocyte precursor cell | 8 studies | 29% ± 11% | |
GABAergic neuron | 7 studies | 46% ± 21% | |
neuron | 7 studies | 34% ± 19% | |
microglial cell | 7 studies | 27% ± 7% | |
type I pneumocyte | 6 studies | 20% ± 5% | |
adventitial cell | 5 studies | 32% ± 10% | |
cardiac muscle cell | 5 studies | 43% ± 12% | |
epithelial cell | 5 studies | 35% ± 14% | |
basal cell | 5 studies | 28% ± 12% | |
endothelial cell of sinusoid | 4 studies | 40% ± 12% | |
glomerular endothelial cell | 4 studies | 95% ± 1% | |
glial cell | 4 studies | 29% ± 11% | |
luminal cell of prostate epithelium | 4 studies | 43% ± 26% | |
muscle cell | 4 studies | 36% ± 12% | |
interneuron | 4 studies | 51% ± 19% | |
myoepithelial cell | 4 studies | 41% ± 13% | |
secretory cell | 3 studies | 40% ± 32% | |
mesothelial cell | 3 studies | 39% ± 5% | |
endocardial cell | 3 studies | 32% ± 12% | |
lymphocyte | 3 studies | 34% ± 10% | |
abnormal cell | 3 studies | 38% ± 14% | |
hepatocyte | 3 studies | 47% ± 17% | |
ependymal cell | 3 studies | 45% ± 13% | |
chondrocyte | 3 studies | 23% ± 5% | |
type II pneumocyte | 3 studies | 21% ± 5% | |
gamma-delta T cell | 3 studies | 22% ± 4% | |
Schwann cell | 3 studies | 45% ± 11% | |
goblet cell | 3 studies | 42% ± 27% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 11289.10 | 245 / 245 | 100% | 528.58 | 502 / 502 |
thymus | 100% | 6005.87 | 653 / 653 | 96% | 77.68 | 579 / 605 |
adrenal gland | 99% | 3589.38 | 256 / 258 | 95% | 78.42 | 219 / 230 |
kidney | 99% | 4119.72 | 88 / 89 | 96% | 148.02 | 861 / 901 |
bladder | 100% | 6520.71 | 21 / 21 | 92% | 63.35 | 462 / 504 |
stomach | 98% | 2935.55 | 353 / 359 | 92% | 43.81 | 263 / 286 |
breast | 100% | 7100.55 | 459 / 459 | 90% | 40.42 | 1008 / 1118 |
intestine | 100% | 4864.43 | 966 / 966 | 88% | 33.03 | 464 / 527 |
lung | 99% | 2875.68 | 570 / 578 | 88% | 34.83 | 1021 / 1155 |
skin | 99% | 2423.29 | 1782 / 1809 | 87% | 34.08 | 409 / 472 |
brain | 84% | 1434.12 | 2220 / 2642 | 99% | 51.74 | 699 / 705 |
esophagus | 96% | 2823.41 | 1394 / 1445 | 81% | 26.89 | 148 / 183 |
uterus | 100% | 5089.39 | 170 / 170 | 73% | 38.25 | 337 / 459 |
liver | 80% | 1451.01 | 181 / 226 | 93% | 64.72 | 376 / 406 |
pancreas | 61% | 730.87 | 200 / 328 | 96% | 50.89 | 171 / 178 |
ovary | 69% | 1276.94 | 125 / 180 | 56% | 15.58 | 242 / 430 |
adipose | 100% | 8242.81 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 7514.88 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 35.85 | 1 / 1 |
heart | 96% | 3332.76 | 829 / 861 | 0% | 0 | 0 / 0 |
muscle | 95% | 2080.71 | 764 / 803 | 0% | 0 | 0 / 0 |
spleen | 85% | 1381.39 | 205 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 73% | 22.83 | 33 / 45 |
lymph node | 0% | 0 | 0 / 0 | 48% | 10.97 | 14 / 29 |
eye | 0% | 0 | 0 / 0 | 35% | 8.74 | 28 / 80 |
peripheral blood | 0% | 3.04 | 2 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0006670 | Biological process | sphingosine metabolic process |
GO_0030518 | Biological process | nuclear receptor-mediated steroid hormone signaling pathway |
GO_0007165 | Biological process | signal transduction |
GO_0006672 | Biological process | ceramide metabolic process |
GO_0019216 | Biological process | regulation of lipid metabolic process |
GO_0046839 | Biological process | phospholipid dephosphorylation |
GO_0030149 | Biological process | sphingolipid catabolic process |
GO_0006644 | Biological process | phospholipid metabolic process |
GO_0030521 | Biological process | androgen receptor signaling pathway |
GO_0007205 | Biological process | protein kinase C-activating G protein-coupled receptor signaling pathway |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0016020 | Cellular component | membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005901 | Cellular component | caveola |
GO_0008195 | Molecular function | phosphatidate phosphatase activity |
GO_0106235 | Molecular function | ceramide-1-phosphate phosphatase activity |
GO_0052642 | Molecular function | lysophosphatidic acid phosphatase activity |
GO_0042577 | Molecular function | lipid phosphatase activity |
GO_0000810 | Molecular function | diacylglycerol diphosphate phosphatase activity |
GO_0042392 | Molecular function | sphingosine-1-phosphate phosphatase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | PLPP1 |
Protein name | Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) Phospholipid phosphatase 1 |
Synonyms | PPAP2A LPP1 |
Description | FUNCTION: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P . Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound . Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes . It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P . Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes . May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity). . |
Accessions | ENST00000307259.9 [O14494-1] D6REC3 ENST00000264775.9 [O14494-2] O14494 ENST00000509667.5 |