PLPP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006670Biological processsphingosine metabolic process
GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_0007165Biological processsignal transduction
GO_0006672Biological processceramide metabolic process
GO_0019216Biological processregulation of lipid metabolic process
GO_0046839Biological processphospholipid dephosphorylation
GO_0030149Biological processsphingolipid catabolic process
GO_0006644Biological processphospholipid metabolic process
GO_0030521Biological processandrogen receptor signaling pathway
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005901Cellular componentcaveola
GO_0008195Molecular functionphosphatidate phosphatase activity
GO_0106235Molecular functionceramide-1-phosphate phosphatase activity
GO_0052642Molecular functionlysophosphatidic acid phosphatase activity
GO_0042577Molecular functionlipid phosphatase activity
GO_0000810Molecular functiondiacylglycerol diphosphate phosphatase activity
GO_0042392Molecular functionsphingosine-1-phosphate phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLPP1
Protein namePhospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)
Phospholipid phosphatase 1
SynonymsPPAP2A
LPP1
DescriptionFUNCTION: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P . Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound . Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes . It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P . Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes . May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity). .

AccessionsENST00000307259.9 [O14494-1]
D6REC3
ENST00000264775.9 [O14494-2]
O14494
ENST00000509667.5