MANF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	27 studies	26% ± 11%	Explore
plasma cell	26 studies	54% ± 19%	Explore
natural killer cell	25 studies	24% ± 6%	Explore
endothelial cell	20 studies	28% ± 11%	Explore
plasmacytoid dendritic cell	18 studies	37% ± 13%	Explore
CD8-positive, alpha-beta T cell	18 studies	23% ± 10%	Explore
T cell	13 studies	24% ± 7%	Explore
macrophage	13 studies	26% ± 11%	Explore
epithelial cell	12 studies	35% ± 20%	Explore
pericyte	12 studies	25% ± 7%	Explore
basal cell	12 studies	30% ± 11%	Explore
plasmablast	11 studies	62% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	21% ± 3%	Explore
conventional dendritic cell	11 studies	23% ± 9%	Explore
myofibroblast cell	11 studies	21% ± 5%	Explore
connective tissue cell	11 studies	32% ± 9%	Explore
smooth muscle cell	11 studies	22% ± 6%	Explore
mast cell	11 studies	24% ± 5%	Explore
CD4-positive, alpha-beta T cell	10 studies	26% ± 13%	Explore
mature NK T cell	10 studies	19% ± 4%	Explore
IgG plasma cell	9 studies	42% ± 15%	Explore
gamma-delta T cell	9 studies	24% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 5%	Explore
goblet cell	8 studies	26% ± 11%	Explore
IgA plasma cell	8 studies	48% ± 16%	Explore
ciliated cell	8 studies	30% ± 10%	Explore
mucosal invariant T cell	7 studies	18% ± 3%	Explore
capillary endothelial cell	7 studies	21% ± 6%	Explore
endothelial cell of vascular tree	7 studies	27% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 4%	Explore
endothelial cell of artery	6 studies	24% ± 8%	Explore
vein endothelial cell	6 studies	22% ± 6%	Explore
monocyte	6 studies	22% ± 4%	Explore
innate lymphoid cell	6 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	6 studies	30% ± 10%	Explore
secretory cell	6 studies	30% ± 8%	Explore
classical monocyte	5 studies	28% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	27% ± 11%	Explore
leukocyte	5 studies	26% ± 7%	Explore
hematopoietic precursor cell	5 studies	32% ± 15%	Explore
progenitor cell	5 studies	24% ± 3%	Explore
enteroendocrine cell	5 studies	29% ± 12%	Explore
abnormal cell	5 studies	19% ± 3%	Explore
myeloid cell	5 studies	27% ± 10%	Explore
regulatory T cell	5 studies	27% ± 12%	Explore
dendritic cell	5 studies	31% ± 11%	Explore
club cell	4 studies	23% ± 4%	Explore
pancreatic A cell	4 studies	37% ± 15%	Explore
non-classical monocyte	4 studies	19% ± 3%	Explore
mononuclear phagocyte	4 studies	27% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	22% ± 3%	Explore
kidney loop of Henle epithelial cell	4 studies	19% ± 3%	Explore
transit amplifying cell	4 studies	23% ± 2%	Explore
mesothelial cell	4 studies	30% ± 15%	Explore
IgM plasma cell	4 studies	40% ± 14%	Explore
duct epithelial cell	3 studies	17% ± 0%	Explore
pancreatic D cell	3 studies	49% ± 16%	Explore
type B pancreatic cell	3 studies	47% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	24% ± 5%	Explore
renal alpha-intercalated cell	3 studies	26% ± 6%	Explore
neural crest cell	3 studies	23% ± 4%	Explore
extravillous trophoblast	3 studies	46% ± 16%	Explore
placental villous trophoblast	3 studies	36% ± 10%	Explore
lymphocyte	3 studies	26% ± 10%	Explore
adventitial cell	3 studies	27% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 7%	Explore
exhausted T cell	3 studies	16% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	29% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	33% ± 10%	Explore
memory B cell	3 studies	20% ± 5%	Explore
granulocyte	3 studies	21% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	25% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	56% ± 21%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	26% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	25% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	26% ± 8%	Explore
intestine	9 studies	24% ± 10%	Explore
peripheral blood	7 studies	21% ± 4%	Explore
kidney	5 studies	19% ± 4%	Explore
liver	5 studies	18% ± 5%	Explore
pancreas	4 studies	39% ± 19%	Explore
placenta	3 studies	39% ± 12%	Explore
bone marrow	3 studies	23% ± 6%	Explore
uterus	3 studies	34% ± 16%	Explore
prostate	3 studies	29% ± 6%	Explore
brain	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	3078.74	328 / 328	100%	115.67	178 / 178
prostate	100%	2768.42	245 / 245	100%	161.44	502 / 502
stomach	100%	2494.82	359 / 359	100%	102.75	286 / 286
bladder	100%	2736.14	21 / 21	100%	144.43	503 / 504
uterus	100%	2268.88	170 / 170	100%	142.61	458 / 459
ovary	100%	1800.47	180 / 180	100%	96.57	429 / 430
intestine	100%	2159.72	965 / 966	100%	121.87	526 / 527
thymus	100%	6827.23	653 / 653	100%	140.78	603 / 605
breast	100%	2130.58	459 / 459	99%	111.97	1110 / 1118
lung	100%	3167.59	576 / 578	99%	111.05	1148 / 1155
esophagus	100%	2140.17	1443 / 1445	99%	62.63	181 / 183
kidney	100%	2673.33	89 / 89	99%	59.68	888 / 901
skin	100%	3241.01	1809 / 1809	99%	108.53	465 / 472
liver	98%	4570.91	222 / 226	100%	127.90	406 / 406
adrenal gland	100%	2309.48	258 / 258	95%	71.17	218 / 230
brain	91%	976.06	2406 / 2642	99%	62.73	696 / 705
lymph node	0%	0	0 / 0	100%	139.03	29 / 29
spleen	100%	3806.23	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	90.94	45 / 45
ureter	0%	0	0 / 0	100%	133.46	1 / 1
blood vessel	100%	2817.20	1332 / 1335	0%	0	0 / 0
adipose	100%	2164.46	1201 / 1204	0%	0	0 / 0
heart	97%	2095.07	831 / 861	0%	0	0 / 0
peripheral blood	92%	1973.77	852 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	88%	31.19	70 / 80
muscle	42%	332.68	337 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0002014	Biological process	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
GO_0006986	Biological process	response to unfolded protein
GO_0031175	Biological process	neuron projection development
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_1905897	Biological process	regulation of response to endoplasmic reticulum stress
GO_0005615	Cellular component	extracellular space
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0033018	Cellular component	sarcoplasmic reticulum lumen
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0120146	Molecular function	sulfatide binding
GO_0008083	Molecular function	growth factor activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	MANF
Protein name	Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET) Mesencephalic astrocyte derived neurotrophic factor
Synonyms	ARMET ARP
Description	FUNCTION: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain . Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death . Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions . Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia . Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells . Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions . .
Accessions	ENST00000446668.5 H7C2D6 P55145 ENST00000528157.7

MANF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review